A saggital cross section of a mouse brain is richly stained in three distinct colors in three distinct areas: yellow in the very front and about halfway toward the back; green in a large area toward the front and cyan across wide areas, especially the cerebellum in the back
January 24, 2025
MIT method enables ultrafast protein labeling of tens of millions of densely packed cells in organ-scale tissues
Emery N. Brown stands in front of a wall. Superimposed on the image next to him is a picture of the front of the National Medal of Science, which depicts a man kneeling and drawing an abstract character in the ground next to him as he contemplates an object.
January 3, 2025
Emery N. Brown, innovative neuroscientist, statistician and anesthesiologist earns National Medal of Science
Two colorful arrays of dots are side by side. The left array, labeled session 1, is in a vaguely circular shape. The right array, labeled session 5, is in a structure similar to a sideways T, which is the actual shape of the maze that mice ran through.
December 10, 2024
Study suggests how the brain, with sleep, learns meaningful maps of spaces
A 3D cartoon of a mouse jumping around on a landscape of white hexagonal pillars. The mouse's trajectory through time is noted with a wiggly blue line. The mouse wears electronics on the back of its head and a small thin wire comes up out of them.
November 13, 2024
Open technology platform enables new versatility for neuroscience research with more naturalistic behavior
A cartoon shows a head in profile split between a gray region at the front and a green region at the back. In the back is a bell and progressively larger dotted white circles propagate outward from the bell toward the front of the head.
October 7, 2024
The way sensory prediction changes under anesthesia tells us how conscious cognition works

Researchers map brain cell changes in Alzheimer’s disease

February 2, 2023
Study reveals key cell structures and gene expression changes near amyloid plaques and tau tangles in mouse brain tissue

How Huntington’s disease affects different neurons

January 20, 2023
Research Findings
A new study identifies cells that are the most vulnerable within a brain structure involved in mood and movement

Self-assembling proteins can store cellular “memories”

January 10, 2023
Research Findings
Using these engineered proteins, researchers can record histories that reveal when certain genes are activated or how cells respond to a drug.

New technologies revealing cross-cutting breakdowns in Alzheimer’s disease

January 2, 2023
Research Findings
‘Single-cell profiling’ is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways

Holding information in mind may mean storing it among synapses

December 29, 2022
Research Findings
Comparing models of working memory with real-world data, MIT researchers found that information resides not in persistent neural activity, but in the pattern of their connections

Small studies of 40Hz sensory stimulation confirm safety, suggest Alzheimer’s benefits

December 1, 2022
Research Findings
MIT researchers report early stage clinical study results of tests with non-invasive 40Hz light and sound treatment

Research offers insights into mechanisms underlying bipolar mania, sleep homeostasis

November 23, 2022
Recent Events
At a press conference at Society for Neuroscience Annual Meeting, young Picower scientist Takato Honda presented findings of key neurons involved in the neuropsychiatric disorder and sleep homeostasis

Alzheimer’s risk gene undermines insulation of brain’s “wiring”

November 16, 2022
Research Findings
In people carrying the APOE4 risk variant, a key brain cell type mismanages cholesterol needed to insulate neurons properly—another sign that APOE4 contributes to disease by disrupting lipids in the brain

Analyzing brain waves demystifies general anesthesia

November 14, 2022
Recent Events
At Neuroscience 2022, Emery N. Brown relayed how statistical analysis of brain rhythms in patients and animals under anesthetics has revealed important information about how the drugs work.

Are covid ‘comas’ signs of a protective hibernation state?

November 7, 2022
Research Findings
Scientists hypothesize that, as in a hibernating turtle, the brain under sedation and deprived of oxygen may assume a protective state

Bear elected member of National Academy of Medicine

October 17, 2022
Picower People
Academy recognizes Mark Bear’s influential fundamental research on how experience shapes the brain and its relevance to neurodevelopmental diseases.

Building a bridge between neuroscience and immunology

October 14, 2022
Picower People
Gloria Choi’s studies of how the immune system and nervous system influence each other could yield new approaches to treating neurological disorders.