A microscope view of several worms wriggling through a red-hued gel
April 20, 2026
How neurons sense bacteria in the gut
Three views of an organoid cell culture show the constiuent cells of the vaguely round, tangled mass of cells.  In the different views the cells are highlighted in different colors such as magenta and green.
April 14, 2026
Rett syndrome study highlights potential for personalized treatments
A video screenshot shows a grayscale worm twisting its body around in a loop to change direction
April 10, 2026
With navigating nematodes, scientists map out how brains implement behaviors
A member of a surgical staff holds a mask on the face of an unconscious patient in an operating room
March 17, 2026
Three anesthesia drugs all have the same effect in the brain, MIT researchers find
Li-Huei Tsai stands at a podium embossed with an MIT logo. In the foreground is an attentive audience. In the background is the Picower Institute logo
March 11, 2026
After 16+ years leading Picower Institute, Li-Huei Tsai will sharpen focus on research, teaching

Feast or forage: Study finds circuit that helps a brain decide

November 22, 2021
Research Findings
By integrating multiple sensory inputs, a loop of mutual inhibition among a small set of neurons allows worms to switch between long-lasting behavioral states

Young Picower scientists present projects at ‘SfN’

November 12, 2021
Picower People
Picower scientists shared research on brain waves, new technologies, brain plasticity and psychiatric illness and, of course, learning and memory.

Study links gene to cognitive resilience in the elderly

November 3, 2021
Research Findings
The findings may help explain why some people who lead enriching lives are less prone to Alzheimer’s and age-related dementia

Symposium spotlights crucial roles of dendrites

October 18, 2021
Recent Events
Scholars from around the world gathered online to share new research on how intricately structured neural processes enable plasticity of circuit connections and help integrate incoming information to enable brain function

NIH award funds innovative investigation of neurodegenerative motor diseases

October 5, 2021
New Research
Large-scale, integrated application of advanced computational, biological techniques aims to discover mechanisms underlying ALS and frontotemporal lobar degeneration with motor neuron disease

Study shows fragile X treatment can incur resistance, suggests ways around it

September 29, 2021
Research Findings
While the brain acquires resistance to continuous treatment with mGluR5 inhibitor drugs, lasting effects may still arise if dosing occurs intermittently and during a developmental critical period

'What Were you Thinking?'

September 20, 2021
Research Feature
How brain circuits integrate many sources of context to flexibly guide behavior

From Brazil to Fenway Park, researcher strives to save lives with science

September 10, 2021
Picower People
As a researcher studying Huntington’s disease, and as a science communicator working tirelessly to keep Portuguese- and Spanish-speaking communities informed about Covid-19, Izabella Pena is focused on keeping people safe.

Behind the scenes, brain circuit ensures vision remains reliable

September 8, 2021
As mice watched movies, scientists watched their brains to see how vision could be represented reliably. The answer is that consistency in representation is governed by a circuit of inhibitory neurons

Statistical model defines ketamine anesthesia’s effects on the brain

September 3, 2021
Research Findings
Neuroscientists at MIT and Massachusetts General Hospital have developed a statistical framework that rigorously describes the brain state changes that patients experience under ketamine-induced anesthesia.

Novel approach reverses amblyopia in animals

September 1, 2021
Research Findings
By temporarily suspending retinal activity in the non-amblyopic eye of animal models, neuroscientists restrengthened the visual response in the amblyopic eye, even at ages after the critical period when patch therapy fails

A pivot from accounting to neuroscience

August 26, 2021
Picower People
Through a summer research program at MIT, Patricia Pujols explored the neuromuscular junction, and a future in science.