Li-Huei Tsai stands at a podium embossed with an MIT logo. In the foreground is an attentive audience. In the background is the Picower Institute logo
March 11, 2026
After 16+ years leading Picower Institute, Li-Huei Tsai will sharpen focus on research, teaching
Two panels show blue cells surrounded by thin green outlines. The outlines are much more consistent and prevalent in the image on the left, which is labeled as the wild type, than on the right which is labeled Rett syndrome.
February 25, 2026
In Rett syndrome, leaky brain blood vessels traced to microRNA
a series of small blocky spots of color appear in the aggregate to make up the shape of a worm as it stretches horizonally across a black background
February 24, 2026
As worms and jellyfish wriggle, new AI tools track their neurons
Linlin Fan stands in her lab with microscope equipment in the foreground.
February 17, 2026
Sloan Fellowship will help Fan advance technology to study how brain circuits change amid learning
Wearing white lab coats in the lab, Mark Bear stands behind Sara Kornfeld-Sylla as she sits in a stool at a lab bench
February 11, 2026
Fragile X study uncovers brainwave biomarker bridging humans and mice

In ‘minibrains,’ hindering key enzyme by different amounts has opposite growth effects

May 10, 2021
Research Findings
Surprising findings can help improve organoid cultures, explain role of GSK3-beta in brain development

New algorithms show accuracy, reliability in gauging unconsciousness under general anesthesia

May 6, 2021
Research Findings
Machine learning software advances could help anesthesiologists optimize drug dose

Anesthesia doesn't simply turn off the brain, it changes its rhythms

April 27, 2021
Research Findings
Simultaneous measurement of neural rhythms and spikes across five brain areas in animals reveals how propofol induces unconsciousness

Li-Huei Tsai elected to American Academy of Arts & Sciences

April 22, 2021
Picower People
AAAS honors professor whose lab focuses on understanding Alzheimer's disease and developing innovative treatment strategies

Tiny brains grown in 3D-printed bioreactor

April 7, 2021
Research Findings
Small device contains wells to let small bits of tissue grow, develop, and be studied in real time

Mice naturally engage in physical distancing, study finds

March 31, 2021
Research Findings
MIT neuroscientists have identified a brain circuit that stops mice from mating with others that appear to be sick

Study of synapse strength focuses on ‘active zones’

March 16, 2021
New Research
With new NIH grant, team will learn how neurons build key sites that release neurotransmitters a lot, or a little, to drive nervous system communication

Bigger than a Building

March 10, 2021
Picower People
Our first ever census of alumni and former research staff shows a thriving community that spans the globe and many different roles

Neural networks need more than neurons, new project posits

March 4, 2021
New Research
With a new grant from the U.S. Army, a team of scientists will seek to enhance artificial intelligence by integrating brain cells called astrocytes

Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk

March 3, 2021
Research Findings
The gene variant disrupts lipid metabolism, but in cell experiments the effects were reversed by choline supplements

Basic cell health systems wear down in Huntington’s disease, novel analysis shows

February 23, 2021
Research Findings
A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis

Steven Flavell earns Sloan Research Fellowship

February 16, 2021
Picower People
Award supports fundamental research on how the brain generates internal states that guide animal behavior