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Cognition and Motivation
Systems Neuroscience
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Memory Systems

Memories can be of many types (e.g. places or faces), operate on different timeframes (long- or short-term), and be stored and recalled through distinct processes involving multiple brain regions. The subject of intense interest across the Picower Institute, memory systems are studied widely and in depth.  

Visual System

Perhaps the most prized of our senses, the visual system has long provided neuroscientists a model for studying neural plasticity and development and cortical dynamics. It also is a system in which disorders can produce devastating disabilities. At the Picower Institute, scientists study this system to gain broad insights into the brain and also to address societal needs.

Neuro Genomics and Proteomics

Fundamentally the central nervous system is made up of cells whose functions are specified by which genes are expressed, and how and when.  At the Picower Institute, scientists use “big data” and bio-informatics techniques to make new discoveries about how genes and the proteins that arise from their expression influence brain function and how abnormalities contribute to disease.

Brain Imaging

In many ways, Picower Institute neuroscientists are explorers for whom new ways to see inside the brain are essential for finding answers to their questions about how the brain works at scales ranging from synapses to whole networks. Researchers at the institute doesn’t just apply the latest imaging techniques, it often creates new technologies to make imaging better.

Symposium highlights MIT’s wide range of innovations for aging brain health

September 30, 2026
Picower Events
In six talks Sept. 25, researchers from across MIT described projects aimed at advancing the understanding of and interventions against neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS

Brain Biomarkers

September 29, 2026
Research Feature
Brain disorders are notoriously mysterious. To improve diagnosis and to better measure treatment efficacy, Picower Institute labs are developing objective and minimally invasive indicators of brain health.

How the brain keeps its options straight at decision time

September 9, 2026
Research Findings
Making a decision requires juggling a set of options without getting them confused or losing track of them. A new MIT study shows how ensembles of neurons encode information to maximize clarity throughout the process.

A burst of “pink noise” may lead to more restorative sleep

September 9, 2026
Research Findings
Delivered at just the right time, this type of auditory stimulus can strengthen the flow of cerebrospinal fluid, which clears debris from the brain and keeps it healthy.

Atlas of the brain’s striatum could guide researchers to new drug treatments

September 1, 2026
Research Findings
A new study reveals insights into populations of neurons affected by Huntington’s disease, schizophrenia, addiction, and other disorders.

Cognition and consciousness arise from analog computations, says new theory

August 19, 2026
Research Findings
The brain's ability to generate quick, nimble volitional thought—and a unified awareness of thought and experience—arises from analog computations carried out by electrical waves, MIT neuroscientists argue in a new review

Flexible brain circuits can switch between different tasks

August 17, 2026
Research Findings
Neuroscientists have discovered circuits in the prefrontal cortex that can be repurposed to store different types of information.

High-speed microscopy reveals electrical activity across the brain

August 14, 2026
Research Findings
The new technique could help scientists learn how the entire brain works to generate decisions and emotions.