Select Topics
Disorders
Cognition and Motivation
Systems Neuroscience
Molecular and Cellular
Neurotechnology

Motivation and Behavior

Our desires and fears often govern our actions. Those motivations and behaviors are, in turn, encoded in the brain via circuits that connect different regions. Picower researchers study them in detail to understand how they function and how abnormalities may result in diseases such as addiction.

Arousal Control

Whether awake, asleep or under anesthesia, the brain operates in various states of consciousness, often for prolonged periods. Picower researchers study the biochemistry and systems that generate and govern consciousness and arousal both to achieve basic understanding and to improve clinical care.

Memory Systems

Memories can be of many types (e.g. places or faces), operate on different timeframes (long- or short-term), and be stored and recalled through distinct processes involving multiple brain regions. The subject of intense interest across the Picower Institute, memory systems are studied widely and in depth.  

Visual System

Perhaps the most prized of our senses, the visual system has long provided neuroscientists a model for studying neural plasticity and development and cortical dynamics. It also is a system in which disorders can produce devastating disabilities. At the Picower Institute, scientists study this system to gain broad insights into the brain and also to address societal needs.

Picower Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86

July 15, 2026
Picower People
Tonegawa made landmark discoveries about how the immune system generates antibody diversity and how the brain forms memories.

Electric fields help guide neural activity, even from moment to moment

July 7, 2026
Research Findings
A new study adds evidence that electric fields in the brain help to organize and shape underlying neural activity via “ephaptic coupling.”

Symposium speakers examine how understanding the brain could improve the functioning of democracy

June 2, 2026
Picower Events
Combining insights from the debates of American civics to the discoveries of neuroscience labs, experts honed in on ways that brain science research could inform efforts to improve political participation and dialogue in a polarized age

Myriam Heiman named the director of The Picower Institute for Learning and Memory

May 26, 2026
Picower People
Heiman, who studies neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease, will lead the institute beginning July 1.

Takato Honda receives MIT Infinite Expansion Award

May 22, 2026
Picower People
Picower Institute Research Scientist honored for studies, mentoring and recently discovering a new marine species

The rules neurons follow to make sense of what we see

May 14, 2026
Research Findings
Brain cells take in many signals through thousands of circuit connections. A new study in mice discerns the rules that turn what could be a cacophony of inputs into a functional arrangement for neurons that process vision.

MIT-based team releases first AI foundation model for Alzheimer's prevention

April 26, 2026
Research Feature
FINGERS-7B integrates lifestyle, clinical, genomic, and proteomic data from tens of thousands of at-risk individuals to discover multi-omic biomarkers for preclinical Alzheimer's

How neurons sense bacteria in the gut

April 20, 2026
Research Findings
Neural interaction with bacteria, e.g. in the gut microbiome, has important effects on brains of animals from worms to people. A new study investigates how neurons sense bacteria by revealing, in nematodes, the bacterial signals that a key neuron detects