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Disorders
Cognition and Motivation
Systems Neuroscience
Molecular and Cellular
Neurotechnology

Brain Imaging

In many ways, Picower Institute neuroscientists are explorers for whom new ways to see inside the brain are essential for finding answers to their questions about how the brain works at scales ranging from synapses to whole networks. Researchers at the institute doesn’t just apply the latest imaging techniques, it often creates new technologies to make imaging better.

Autism Spectrum Disorders

Autism refers to a group of developmental disorders typically affecting behaviors including social interaction. Picower researchers study the neurobiology underlying a variety of forms of autism, including genetic anomalies and other ways that synapses and neural circuits may develop differently. Their studies extend to the level of cognitive functions and associated systems.

Huntington's Disease

Huntington’s disease is an inherited, progressive, neurodegenerative disorder associated with mutation of the Huntingtin protein results in wide-ranging motor, cognitive and behavioral symptoms. Work at the Picower Institute involves advancing the understanding of how the mutation gives rise to these consequences.

Schizophrenia

A developmental disorder with typical onset in young adulthood, schizophrenia affects cognition and behavior, sometimes affecting a person’s understanding of reality. Research in the Picower Institute spans synapses and systems to help better understand the condition and how treatments might be improved.

The rules neurons follow to make sense of what we see

May 14, 2026
Research Findings
Brain cells take in many signals through thousands of circuit connections. A new study in mice discerns the rules that turn what could be a cacophony of inputs into a functional arrangement for neurons that process vision.

MIT-based team releases first AI foundation model for Alzheimer's prevention

April 26, 2026
Research Feature
FINGERS-7B integrates lifestyle, clinical, genomic, and proteomic data from tens of thousands of at-risk individuals to discover multi-omic biomarkers for preclinical Alzheimer's

How neurons sense bacteria in the gut

April 20, 2026
Research Findings
Neural interaction with bacteria, e.g. in the gut microbiome, has important effects on brains of animals from worms to people. A new study investigates how neurons sense bacteria by revealing, in nematodes, the bacterial signals that a key neuron detects

Rett syndrome study highlights potential for personalized treatments

April 14, 2026
Research Findings
Using advanced human cell cultures to model Rett syndrome, MIT researchers tracked how two different mutations alter neural circuit development and how each could be addressed with distinct potential therapeutics

Alana Down Syndrome Center symposium highlights studies from brain to heart

April 14, 2026
Picower Events
Seven researchers from MIT, Rutgers University and the University of São Paulo shared the research they are doing to help people with trisomy 21 throughout their lifespan.

A complete rethinking of how our brains use categories to make sense of the world

April 13, 2026
Research Findings
Challenging the classic view, two cognitive scientists argue in a new review that categorization is not a late, specialized stage of sensory processing. Instead, it is a core function operating at every level, anticipating bodily needs and motor plans.

With navigating nematodes, scientists map out how brains implement behaviors

April 10, 2026
Research Findings
How do nervous systems produce behaviors? A new MIT study provides a detailed mechanistic mapping of exactly what happens in the brains of C. elegans worms when they “follow their nose” to savor attractive odors or avoid unappealing ones

Leading with rigor, kindness, and care

April 2, 2026
Picower People
“We cannot be effective scientists if we are unhappy or unhealthy outside of the lab,” says “Committed to Caring” honoree Sara Prescott.