Fundamentally the central nervous system is made up of cells whose functions are specified by which genes are expressed, and how and when.  At the Picower Institute, scientists use “big data” and bio-informatics techniques to make new discoveries about how genes and the proteins that arise from their expression influence brain function and how abnormalities contribute to disease.

In many ways, Picower Institute neuroscientists are explorers for whom new ways to see inside the brain are essential for finding answers to their questions about how the brain works at scales ranging from synapses to whole networks. Researchers at the institute doesn’t just apply the latest imaging techniques, it often creates new technologies to make imaging better.

Autism refers to a group of developmental disorders typically affecting behaviors including social interaction. Picower researchers study the neurobiology underlying a variety of forms of autism, including genetic anomalies and other ways that synapses and neural circuits may develop differently. Their studies extend to the level of cognitive functions and associated systems.

Huntington’s disease is an inherited, progressive, neurodegenerative disorder associated with mutation of the Huntingtin protein results in wide-ranging motor, cognitive and behavioral symptoms. Work at the Picower Institute involves advancing the understanding of how the mutation gives rise to these consequences.