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Disorders
Cognition and Motivation
Systems Neuroscience
Molecular and Cellular
Neurotechnology

Reward Systems

Learning and motivation are often governed by the experience of reward and the desire to obtain it again. At the same time, some diseases such as addiction hijack this system. Researchers at Picower study these systems to gain insight into the mechanisms of healthy and unhealthy behavior.

Neural Signal Processing

Neurons are electrically active, producing patterns of activity that can be observed to understand their function. By developing advanced techniques to detect and analyze these patterns of electrical signals, Picower Institute scientists can advance the study of how brain circuits, for instance for storing and recalling memory, work.

Activity Sensors

To understand role of neurons and the circuits in which they participate neuroscientists must be able to gather data on a neuron’s electrical activity, such as when they fire, in real-time. Picower scientists are constantly innovating new genetic and chemical sensors, as well as electronic and imaging-based means to track neural activity both in vitro and in vivo and develop sophisticated means to analyze the large volumes of data gathered.

Optogenetics

By engineering cells with light-responsive ion channels, optogenetics allow the activity of cells such as neurons to become controlled by pulses of visible light. The technology is widely used throughout the institute in experiments in which purposeful instigation or suppression of neural activity can reveal important data on the functions of cells, circuits, systems, and behaviors.

Symposium examines the neural circuits that keep us alive and well

October 28, 2025
Picower Events
Seven speakers from around the country convened at MIT to describe some of the latest research on the neural mechanisms that we need to survive.

Small study suggests 40Hz sensory stimulation may benefit some Alzheimer’s patients for years

October 27, 2025
Research Findngs
Five volunteers continued receiving 40Hz stimulation for around two years after an early-stage MIT clinical study. Those with late-onset Alzheimer’s performed significantly better on assessments than comparable Alzheimer’s patients outside the trial

MIT-based team advances to semi-finals of Gates-funded competition to apply ’agentic’ AI to studying Alzheimer’s

October 21, 2025
New Research
“FINGERPRINT,” proposes to use AI to link discovery, prevention, therapy by reasoning across multiple biological and clinical data sets.

Like radar, a brain wave sweeps a cortical region to read out information held in working memory

October 20, 2025
Research Findngs
When spotting what’s changed from one scene to the next, performance will depend on a low-frequency “theta” brain wave that scans the mental image, a new MIT study shows.

MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery

October 17, 2025
Research Findngs
Cultured from induced pluripotent stem cells, ‘miBrains’ integrate all major brain cell types and model brain structures, cellular interactions, activity, and pathological features.

Study finds circular RNA helps drive brain development

October 16, 2025
Research Findngs
MIT neuroscientists show in a new study that loops of RNA can strongly influence how neurons build circuit connections, or synapses, during the development of the visual system in young mice.

Neural activity helps circuit connections mature into optimal signal transmitters

October 14, 2025
Research Findngs
By carefully tracking the formation and maturation of synaptic active zones in fruit flies, MIT scientists have discovered how neural activity helps circuit connections become tuned to the right size and degree of signal transmission

Many Mechanisms of Mood

September 29, 2025
Research Feature
Picower Institute studies reveal a number of ways moods emerge in the brain and therefore many potential paths to address depression, PTSD, anxiety and bipolar disorder.