Huntington’s disease is an inherited, progressive, neurodegenerative disorder associated with mutation of the Huntingtin protein results in wide-ranging motor, cognitive and behavioral symptoms. Work at the Picower Institute involves advancing the understanding of how the mutation gives rise to these consequences.

A developmental disorder with typical onset in young adulthood, schizophrenia affects cognition and behavior, sometimes affecting a person’s understanding of reality. Research in the Picower Institute spans synapses and systems to help better understand the condition and how treatments might be improved.

What we learn and remember help make us who we are. By studying how these systems arise from the contributions of specific genes, molecules, cells, synapses, circuits and systems, Picower scientists make discoveries about how we retain and make use of experiences in the world. By better understanding how these processes may break down, they generate innovative potential treatments and diagnostic methods for complex developmental, psychiatric and degenerative brain disorders.

Computational neuroscience is the study of brain function in terms of the nervous system’s information processing capabilities, such as those exhibited by neurons as they interact in circuits, ensembles and systems via electrical and chemical signals. Computational neuroscience models allow for generating hypotheses about learning and memory, cognition and arousal among other brain functions.