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Disorders
Cognition and Motivation
Systems Neuroscience
Molecular and Cellular
Neurotechnology

Memory Systems

Memories can be of many types (e.g. places or faces), operate on different timeframes (long- or short-term), and be stored and recalled through distinct processes involving multiple brain regions. The subject of intense interest across the Picower Institute, memory systems are studied widely and in depth.  

Visual System

Perhaps the most prized of our senses, the visual system has long provided neuroscientists a model for studying neural plasticity and development and cortical dynamics. It also is a system in which disorders can produce devastating disabilities. At the Picower Institute, scientists study this system to gain broad insights into the brain and also to address societal needs.

Neuro Genomics and Proteomics

Fundamentally the central nervous system is made up of cells whose functions are specified by which genes are expressed, and how and when.  At the Picower Institute, scientists use “big data” and bio-informatics techniques to make new discoveries about how genes and the proteins that arise from their expression influence brain function and how abnormalities contribute to disease.

Brain Imaging

In many ways, Picower Institute neuroscientists are explorers for whom new ways to see inside the brain are essential for finding answers to their questions about how the brain works at scales ranging from synapses to whole networks. Researchers at the institute doesn’t just apply the latest imaging techniques, it often creates new technologies to make imaging better.

MIT-based team releases first AI foundation model for Alzheimer's prevention

April 26, 2026
Research Feature
FINGERS-7B integrates lifestyle, clinical, genomic, and proteomic data from tens of thousands of at-risk individuals to discover multi-omic biomarkers for preclinical Alzheimer's

How neurons sense bacteria in the gut

April 20, 2026
Research Findings
Neural interaction with bacteria, e.g. in the gut microbiome, has important effects on brains of animals from worms to people. A new study investigates how neurons sense bacteria by revealing, in nematodes, the bacterial signals that a key neuron detects

Alana Down Syndrome Center symposium highlights studies from brain to heart

April 14, 2026
Picower Events
Seven researchers from MIT, Rutgers University and the University of São Paulo shared the research they are doing to help people with trisomy 21 throughout their lifespan.

Rett syndrome study highlights potential for personalized treatments

April 14, 2026
Research Findings
Using advanced human cell cultures to model Rett syndrome, MIT researchers tracked how two different mutations alter neural circuit development and how each could be addressed with distinct potential therapeutics

A complete rethinking of how our brains use categories to make sense of the world

April 13, 2026
Research Findings
Challenging the classic view, two cognitive scientists argue in a new review that categorization is not a late, specialized stage of sensory processing. Instead, it is a core function operating at every level, anticipating bodily needs and motor plans.

With navigating nematodes, scientists map out how brains implement behaviors

April 10, 2026
Research Findings
How do nervous systems produce behaviors? A new MIT study provides a detailed mechanistic mapping of exactly what happens in the brains of C. elegans worms when they “follow their nose” to savor attractive odors or avoid unappealing ones

Leading with rigor, kindness, and care

April 2, 2026
Picower People
“We cannot be effective scientists if we are unhappy or unhealthy outside of the lab,” says “Committed to Caring” honoree Sara Prescott.

Brain Simulation

March 23, 2026
Research Feature
Picower Institute researchers and collaborators are inventing versatile new models of the brain to accelerate neuroscience discoveries and biomedical advances.