… Homer1a disrupts synaptic scaffolds that anchor glutamate receptors, weakening “excitatory” synapse function, Sur said. … out, there was less removal of proteins called AMPA receptors, which normally facilitates spine shrinkage. What …
… comes in six different forms, and there are five different receptors that can bind to it. In their two new papers, the researchers set out to map which of these receptors are expressed in different parts of the brain. This mapping revealed that a pair of receptors known as IL-17RA and IL-17RB is found in the …
… with another protein synthesis process driven by other receptors. If the balance moved too far in one way, it led to … side of a synaptic connection to incorporate signaling receptors needed for proper formation and maturation. With an …
… Enhancing activity of a specific component of ‘NMDA’ receptors normalized protein synthesis, neural activity and … Enhancing activity of a specific component of ‘NMDA’ receptors normalized protein synthesis, neural activity and … works by targeting a specific molecular subunit of “NMDA” receptors that they discovered plays a key role in how …
… dopamine? The team showed that indeed they express “D1” receptors for the neuromodulator. Commensurate with the … degree of dopamine connectivity, Ppp1r1b cells had more receptors than Rspo2 neurons. Dopamine does a lot of things, … was to manipulate the amygdala neurons’ dopamine receptors. In Ppp1r1b neurons, overexpressing dopamine …
… broad-based effects quite precisely, finding the right receptors, on the right neurons at the right times in the … and understand basic pharmacology of many serotonin receptors. But these neuromodulators can impact literally … of billions in a human) and has six different serotonin receptors (compared to 14 in people), but that simplicity is …
… modeling what happens when ketamine blocks the “NMDA” receptors in the brain’s cortex—the outer layer where key … processing and cognition take place. Blocking the NMDA receptors modulates the release of excitatory … the neuronal channels (or doorways) regulated by the NMDA receptors open, they typically close slowly (like a doorway …
