… the rapid activity-dependent trafficking of glutamate receptors to the synapse. This trafficking requires the … of proteins that, we discovered which bind to glutamate receptors and act as auxiliary subunits. These proteins are … not only essential for the trafficking of the glutamate receptors, but also control the gating of the receptor …
Thursday, Feb 20
… 2020 New Research New NIH grant funds study that will span receptors, cells, the whole brain and behavior … that express each of the worm’s five distinct serotonin receptors. Moreover, Flavell’s lab has developed an … patterns of serotonin release can stimulate distinct receptors (or combinations of them) on a multitude of neurons …
Friday, Dec 13
… his team expected to confirm that key proteins called NMDA receptors act specifically in neurons in layer 4 of the … Researchers used a genetic technique to knock out NMDA receptors in layer 4 of the visual cortex of mice. The cortex … mixed. However, while the evidence demonstrates that NMDA receptors in layer 4 neurons are indeed necessary for the …
Friday, Jun 22
… obey it. They used a chemical tag to watch how key “AMPA” receptors changed in the synapses and saw that synaptic … with reduced amount of Arc were able to express more AMPA receptors whereas increased Arc in neighboring spines caused those synapses to express less AMPA receptors. “We think Arc maintains a balance of synaptic …
… receptor, an initial member of a growing family of lipid receptors that includes S1P receptors that are targets for two current neuroscience … & siponimod for Multiple Sclerosis) with lysophospholipid receptors also linked to other diseases, including …
Wednesday, Jan 09
… to neural activity, that helps regulate the number of receptors for the neurotransmitter glutamate at excitatory … synapses or that decreased the proper cycling of glutamate receptors within synapses. The findings show how genetic …
Tuesday, Apr 30
… ganglia circuits. These deep brain circuits, which contain receptors that mediate the effects of cannabis, are known to … effects of cannabinoids. Her team recently found that CB1 receptors are tightly linked to dopamine — a neurotransmitter … a member of the McGovern Institute, will examine how CB1 receptors in the striatum, a deep brain structure implicated …
Tuesday, Jul 10
… the typical weak synapse, GluRIIA and GluRIIB containing receptors were pretty much mixed together. But in strong …
… significance of spontaneous release is less clear. Whether receptors on the postsynaptic cell have the ability to … both vesicle release mechanisms activate the same set of receptors, crosstalk would occur between the two modes of … release, indicating a population of postsynaptic receptors is uniquely activated by this mode of vesicle …
