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Protein has unique effects in neural connections related to information processing

October 09, 2018
… currents cognition synapse function synaptic transmission molecular Electrophysiology … Institute for Learning and Memory digs deep into the molecular mechanisms that enable synaptic transmission to … Institute for Learning and Memory digs deep into the molecular mechanisms that enable synaptic transmission to …

Bear elected member of National Academy of Medicine

October 17, 2022
… at MIT, Bear’s lab has made key discoveries about the molecular means by which synapses dynamically change in … much LTD. His lab has discovered that intervening in the molecular mechanisms of LTD can have substantial therapeutic …

Colloquium on the Brain and Cognition with Elena Gracheva, PhD, Yale University

… only):  https://mit.zoom.us/j/99955448546   Cellular, Molecular, and Physiological Adaptations of Hibernation … models alone. Specifically, we are interested in studying molecular evolution of mammalian hibernation and cellular … and starvation. We are also trying to pinpoint the molecular and physiological basis of hibernation induction. …

Petite & Profound

June 22, 2023
… essential to brain health, Littleton’s research into the molecular workings of fly synapses has led him to produce … mammals and begin to look at whether there are conserved molecular networks around the disease protein.” Most Picower … untreatable neurodegenerative disease, by revealing new molecular mechanisms to target for therapies. In 2020 by …

Long-term potentiation in memory

… In the early 1970s neuroscientists discovered that molecular mechanism called “long-term potentiation” enabled … new information that we want to remember, LTP would be the molecular solder for the needed circuit connection. It was … the hippocampus. They found that exactly the same kinds of molecular and electrical changes observed in lab experiments …

Picower Fellows alumni

… disorders, with a specific focus on the cellular and molecular mechanisms leading to experience dependent changes … patients with Rett syndrome, Delepine is exploring the molecular mechanisms underlying neuronal migration deficits … In the Wilson lab, Maria applied her expertise in the molecular mechanisms underlying the distinct subtypes of …

Imaging the brain at multiple size scales

July 25, 2016
… connectivity all the way down to subcellular details, plus molecular information,” he says. To achieve that, the … many times,” Chung says. “You can then use off-the-shelf molecular markers like antibodies to label and visualize the … advance for brain mapping, a technique that reveals the molecular and connectional architecture of the brain with …

Decoding the complexity of Alzheimer’s disease

September 28, 2023
… offer the most detailed picture yet of the genetic and molecular underpinnings of Alzheimer’s. The researchers … to uncover other possible approaches by analyzing the molecular drivers of the disease, the cell types that are the … atlas of the aged human brain reveals cellular and molecular correlates of high cognitive function, dementia, …
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