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… genomic sites is lost, which contributes to loss of cell identity. The role of microglia In a third Cell paper, led by … of high cognitive function, dementia, and resilience to AD Neuronal DNA double-strand breaks lead to genome structural …

… How microglia alter brain infrastructures and influence neuronal activity Abstract: Microglia, traditionally … are involved in establishing and maintaining accurate neuronal circuit function in the retina and in the visual … strategies how to decipher the microglia’s functional identity and how this information guided us to microglia …

… and multi-patching electrophysiology, 3D reconstruction of neuronal morphology, and brain-wide connectivity mapping, to … and 5,322 clusters. We systematically analyzed the neuronal, non-neuronal, and immature neuronal cell types … a high degree of correspondence between transcriptomic identity and spatial specificity for each cell type. We also …

… of a gene called PTB. Data in mice show that after this “identity theft,” as Cleveland termed it, the newly converted … For instance, he’s found that the protein is necessary for neuronal hyperexcitability to emerge in Alzheimer’s disease …

… progenitor projections are in green (anti-vimentin), neuronal projections are in white (anti-B3-tubulin) Albanese … labels targeting specific proteins to highlight cellular identity and activity. With organoids cleared and labeled, …