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… one copy of the APOE4 gene. APOE is a protein involved in lipid transport. Studies show that the APOE4 variant is … pathway, which showed that APOE4-induced dysfunction of lipid metabolism in neurons by cellular accumulation of unsaturated …

… in particular suggested important connections between lipid transport and Alzheimer’s regulated by the vasculature … roles of ApoE, and the increasingly recognized role of lipid metabolism in Alzheimer’s disease.  "Unearthing these …

… Carles Boix, also found that genetic pathways related to lipid metabolism were highly disrupted. In work published in Nature … risk for Alzheimer’s, called APOE4, interferes with normal lipid metabolism, which can then lead to defects in many …

… afflicted cells struggled with mitochondrial function, lipid metabolism, synaptic signaling and maintenance of their …