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… iPS Core Facility The advent of human induced pluripotent stem cells (iPSCs) has heralded a new generation of clinical and … in human cells. The advent of human induced pluripotent stem cells (iPSCs) has heralded a new generation of clinical …

… brain development. To make organoids, scientists take skin cells from a donor, induce them to become stem cells and then culture those in a bioreactor, guiding … factors and other chemicals. Over the course of weeks, the stem cells become progenitor cells that multiply and then go …

… cutting-edge model of the human blood-brain barrier using stem cells to investigate the effects of an Alzheimer’s risk gene. … an assistant professor at Mt. Sinai, he continues to use stem cells to study aging and neurodegenerative disease. In …

… expression of another Alzheimer’s-associated gene in those cells could help alleviate the problem. About 25 percent of … such as these cells derived from induced pluripotent stem cells, are critical for brain function. The research … a series of lab experiments in cultures of stem cell-derived human astrocytes and genetically engineered …

… single-cell profiling, “big data” integration, induced stem-cell reprogramming, mini-brain organoids, tissue … genes and the cell types where they act, and engineer cells, tissues and mouse models to test their hypotheses and … then test these genes/pathways in the induced pluripotent stem cells (iPSC) system coupled with CRISPR-Cas9 to …

… pinpoint mechanism and demonstrate drugs could help stem cells iPSCs neurodegeneration ApoE cerebrovasculature blood … Tsai and co-authors coaxed human induced pluripotent stem cells to become the three types of cells that make up …

… she made the breakthrough discovery that radial glial cells are neural stem cells. This inspired her to attempt turning also adult … injury when she was appointed Director of the Institute of Stem Cell Research at the Helmholtz Center Munich in 2004 and …

… stimulates the release of cytokine molecules from immune cells. Those cytokines reach neurons in the S1DZ region of … in science, technology, engineering and mathematics, or “STEM.”  Mirroring the focus other speakers put on seeking … people at MIT who are working to improve diversity in STEM and participants in some of those programs who described …

… and psychiatric diseases in which access to the affected cells and pathogenic sites is limited. So far, we have … 2009) and genome-edited marmosets (GM) (Sato et al., Cell Stem Cell, 2016). I wish to mention our recent data on the … in the field of regenerative medicine including, neural stem cells and iPS cells, spinal cord injury, developmental …

… perturb brain development.  In 2017 using induced stem cell cultures derived from patients and normal subjects, … combination of advanced imaging methods and human stem cell-derived organoids to  show  that in Rett syndrome, …