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… pinpointed the specific vascular cell type (pericytes) and molecular pathway (calcineurin/NFAT) through which the APOE4 … pericytes’ increased activation of the calcineurin/NFAT molecular pathway appears to encourage the elevated APOE … and expression of the same key genes, proteins and molecular pumps as natural BBBs. When immersed in culture …

… for Learning and Memory report finding a key sequence of molecular events in which the genetic mutation in a fruit fly … in cortex glia cells causes them to hyper-activate a molecular pathway that leads them to withdraw many of the … detailed sequence of events, implicating several specific molecular players and processes. That richly built knowledge …

… that arise—called gliomas—can hijack those cellular and molecular mechanisms. To promote their own growth, gliomas … many other diseases as well), but also revealed specific molecular factors involved. Those findings, Monje said, …

… The Picower Institute for Learning and Memory highlights a molecular mechanism that might help account for the nuanced … of the rare but potent 7B splice form is regulated by a molecular process called phosphorylation. How the much more …

… double major, specializing in both English and molecular, cellular, and developmental biology at Yale … sciences. As an undergraduate, he was in a traditional molecular biology lab. He even planned to stay there after …

… directly impact motor learning, maintaining an optimal molecular balance in which the neuronal ensembles can … In some of the mice, however, the team employed precision molecular interventions to disrupt two specific functions of …

… in my view, the very first map for going after all of the molecular processes that are altered in Alzheimer’s disease … Medical School, described the study as “a tour de force of molecular pathology.” “ This is the first comprehensive … for the field and will advance our understanding of the molecular basis of the disease.” Sex differences The …

… and integrated microsystems for high-throughput imaging, molecular/behavioral phenotyping, and cell microsurgery of a … termed CLARITY , which enables system-wide structural and molecular analysis of large-scale intact biological samples. …

… Hughes Medical Institute investigator. Regev studies the molecular circuitry that governs the function of mammalian … genomics. Her work focuses on dissecting complex molecular networks to determine how they function and evolve …

… who spoke at MIT’s Aging Brain Initiative symposium, “Molecular and Cellular Mechanisms of Neurodegeneration” Sept. … multiple sclerosis called EAE, Schafer has pinpointed the molecular process by which microglia end up engulfing and … In Alzheimer’s model mice, his lab has looked for the molecular culprits that mediate this phenomenon and found …