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… than the more common and risk-neutral APOE3 version, cells called oligodendrocytes mismanage cholesterol, failing … available , encompasses more than 160,000 individual cells of 11 different types from the prefrontal cortex of 32 … why, the team used patient-derived induced pluripotent stem cells to create lab cell cultures of oligodendrocytes …

… the harmful inflammatory response of the brain’s immune cells, reducing disease pathology, preserving neurons and … the harmful inflammatory response of the brain’s immune cells, reducing disease pathology, preserving neurons and … of human microglia-like cells cultured from patient stem cells. When they exposed the microglia-like cells to …

… immune molecule called IL-17a, which is produced by immune cells during a fever, can temporarily reduce some of the … sciences, working with David Anderson. Anderson, a stem cell biologist, was switching his lab’s focus to …

… widespread and debilitating death of nervous system cells, but they also share other grim characteristics: Their … which envelop the brain, becomes a means for immune cells activated by gut bacteria to circulate near the brain … nerve and muscle. These models will be engineered from stem cells derived from patients with ALS. By studying …

… of brain tissue grown from human induced pluripotent stem cells.   “We have developed a 3D model of human myelination … aging and Alzheimer’s disease influence myelinating cells and neuronal health.” Using the cultures, he’ll be able …

… cell types make appear immutable, but the influence those cells have over each other is flexible. The basolateral … Foundation, Alfred P. Sloan Foundation, New York Stem Cell Foundation and the National Institutes of Health …

… Award, the Alfred P. Sloan Foundation, the New York Stem Cell Foundation, the McKnight Foundation, the National …

… to culture cerebral organoids or “minibrains” using stem cells derived from people has given scientists experimentally … A cross-section of an organoid processed with SCOUT shows cells labeled with various antibodies to highlight different …

… of the genes that are expressed in individual brain cells of patients with Alzheimer’s disease. The results … that are affected in neurons and other types of brain cells. This analysis could offer many potential new drug … are now using mouse and human induced pluripotent stem cell models to further study some of the key cellular …

… author Paola Arlotta, the Golub Family Professor of Stem Cell and Regenerative Biology at Harvard University. In …