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40 Hz vibrations reduce Alzheimer’s pathology, symptoms in mouse models

May 18, 2023
… for several weeks showed improved brain health and motor function compared to untreated controls. The MIT group is not … tau, keep neurons from dying or losing their synapse circuit connections, and reduce neural DNA damage. … pathology, and the CK-p25 mouse, which recapitulates the synapse loss and DNA damage seen in human disease. The team …

Look and Learn: Studying the visual system

March 13, 2020
… “Many of us are trying to identify principles of cortical function and plasticity that generalize across cortical areas … CPG15, represents experience to make a newly formed synapse permanent. Synapses come and go, but by manipulating … on V1 neurons, Nedivi’s team showed that when a new synapse participates in a circuit responding to experience, …

The model remodeler

March 14, 2022
… be working to increase or decrease information flow as a function of behavioral change , ” Littleton said.   Built to … of proteins are involved in building and operating e very synapse , both on the “pre-synaptic” (axonal) side and the … the connection. S ome of these proteins contribute to the synapse ’ s structure . Some on the pre-synaptic side …

Troy Littleton

… Institute and the MIT Department of Biology in 2000. Synapse Mapping Neural Plasticity Genetic Engineering Autism … Early Life Stress Brain Imaging Activity Sensors Glia synapse formation synaptic transmission glia epilepsy … shown that association of Cpx with SNAREs allows it to function as a facilitator for synaptic vesicle fusion and as …

‘Rewiring’ cortical circuits

… manifest at the connection between two neurons called a synapse and that most of the synapses neurons form to receive … in this screen were used to restore normal plasticity and function in animal models of brain disorders. In a 2011 … processing a different input strengthened a particular synapse on the neuron. When that happened, the team observed …
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