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Review: Evidence expanding that 40Hz gamma stimulation promotes brain health

March 03, 2025

… gamma Alzheimer's dementia neurodegeneration microglia astrocytes … in many brain cell types including neurons, microglia, astrocytes, oligodendrocytes and the brain’s blood vessels. …

With new grant, MIT neuroscientists will give 'invisible' cells a new look

February 08, 2018

… 'invisible' cells a new look February 8, 2018 New research Astrocytes may 'partner' with neurons to process information astrocytes glia visual cortex synapse development Neurons are … disorders. Above: An astrocyte; Top: Staining highlights astrocytes (red, left) and neurons (green, right). Credit: …

Alzheimer’s risk gene disrupts endocytosis, but another disease-linked gene could help

October 06, 2020

… gene could help October 6, 2020 Research Findings Astrocytes with the APOE4 variant show deficits of key … but overexpressing PICALM overcame the defect endocytosis astrocytes neurodegeneration ApoE … this is so. The new study in Cell Reports finds that in astrocytes, which are the most common non-neuron cell in the …

New grant to study possibility of an immunotherapy for autism

November 02, 2023

… to the brain. neuroimmunology Neuroimmune interactions astrocytes cerebrovasculature Picower Institute-based … with Sur on studies of some of these cells, called astrocytes. Sur’s lab, for instance, will image astrocytes in action as they couple to the brain’s blood …

How sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice

February 28, 2024

… dementia neurodegeneration glymphatics 40Hz amyloid beta astrocytes https://www.nature.com/articles/s41586-024-07132-6 … to the fluid exchange promoted by APQ4 activity in astrocytes, another mechanism by which gamma waves promote …

Imaging the brain at multiple size scales

July 25, 2016

Roots of APOE4-related Alzheimer’s pathology

… brain cells, showed that ApoE4 changes lipid metabolism in astrocytes, causes hyperactivity in neurons and … that drugs corrected the problem in vitro . Above: Human astrocytes carrying the APOE4 gene variant. In a similar vein … APOE4 disruption of lipid metabolism in human iPSC-derived astrocytes could be rescued with doses of the common nutrient …

Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk

March 03, 2021

… They then stimulated these cells to differentiate into astrocytes, the brain cells that produce the most APOE. APOE4 astrocytes showed dramatic changes in how they process lipids compared to APOE3. In APOE4 astrocytes, there was a significant buildup of neutral lipids …

Neuroscientists discover roles of gene linked to Alzheimer’s

May 31, 2018

… higher risk of the disease neurodegeneration microglia astrocytes amyloid beta lipid metabolism … cells to absorb the lipids. In the brain, cells known as astrocytes produce lipids, which are then secreted and taken … into three different types of brain cells: neurons, astrocytes, and microglia. Using the gene-editing system …

How microglia contribute to Alzheimer’s disease

August 04, 2022

… into brain cells, including neurons, microglia, and astrocytes. In a 2018 study , they showed that APOE4 causes … that APOE4 also affects the functions of microglia and astrocytes, leading to cholesterol accumulation, … amyloid beta peptides. A 2021 follow-up showed that APOE4 astrocytes have dramatic impairments in their ability to …