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… as a pathological driver of AD and highlight glycan metabolism as an actional target in the fight against AD.   …

… ABCA7 mutations, the team saw ominous effects on lipid metabolism, DNA damage, and mitochondrial function in … secretion. A key aspect of the pathology turned out to be metabolism of phosphatidylcholine, which helps make …

… disease September 10, 2025 Research Findngs Lipid metabolism and cell membrane function can be disrupted in the … neurons of people who carry rare variants of ABCA7. lipid metabolism neurodegeneration epigenetics mRNA dementia … https://www.nature.com/articles/s41586-025-09520-y Lipid metabolism and cell membrane function can be disrupted in the …

… internal body temperature, and so they will increase metabolism in the cold and then, as energy supplies dwindle, … many animals will engage in a state of radically lowered metabolism called torpor (like hibernation), where body …

… necessary. anesthesia consciousness cognition GABA aging metabolism https://www.pnas.org/doi/10.1073/pnas.2300058120 … exerts these effects through its influence on neuron metabolism. The drug is postulated to disrupt the production … plan to further explore what is happening to the brain’s metabolism during the transition to burst suppression, using …

… August 4, 2022 Research Findings A breakdown of lipid metabolism in these brain cells promotes inflammation and … organoids iPSCs stem cells neurodegeneration ApoE lipid metabolism … A breakdown of lipid metabolism in these brain cells promotes inflammation and … if researchers could find a way to restore normal lipid metabolism in microglia, that might help to treat some of the …

… assume a protective state anesthesia inhibitory neurons metabolism https://www.pnas.org/doi/10.1073/pnas.2120221119 … that are known to improve neurons production of the energy metabolism molecule ATP. This could restore the brain cells’ … counteracting GABA’s tamping down of neural activity and metabolism. “Our analysis predicts the existence of a human …

… targetable pathways Neuroimmune interactions lipid metabolism Neuronal DNA damage neurodegeneration … and immune response Lipid (fat molecule) signaling and metabolism Metabolic stress and protein folding DNA damage …