Research Topics

As this gallery of featured people and projects illustrates, Picower Institute scientists study brain structure and function at scales from genes and molecules to cells, circuits and regions. They also study the behaviors and cognitive processes that result, and seek to uncover how disruptions at different scales can result in developmental, psychiatric or neurodegenerative disorders. They employ—and often invent—the newest technologies in their work. To learn more about any of these specific areas, click "Research Topics" above, select areas of interest, and you'll find relevant Picower people, discoveries and events.

Livestreaming the Brain

March 15, 2024
Research Feature
To learn how the brain works, Picower Institute labs are advancing technologies and methods to watch it live as it happens

A noninvasive treatment for “chemo brain”

March 6, 2024
Research Findings
Stimulating gamma brain waves may protect cancer patients from memory impairment and other cognitive effects of chemotherapy, a new mouse study suggests.

How sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice

February 28, 2024
Research Findings
Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer’s protein via the brain’s glymphatic system, new study suggests.

Study reveals a universal pattern of brain wave frequencies

January 18, 2024
Research Findings
Across mammalian species, brain waves are slower in deep cortical layers, while superficial layers generate faster rhythms.

'Cellf' Expression

December 20, 2023
Research Feature
Picower Institute scientists are using single cell genomics techniques to measure gene expression and produce unque insights into nervous system biology and disease

Nanoparticle-delivered RNA reduces neuroinflammation in lab tests

December 11, 2023
Research Findings
In mice and human cell cultures, MIT researchers showed that novel nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s disease

How a mutation in microglia elevates Alzheimer’s risk

November 16, 2023
Research Findings
A new MIT study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation and contribute to Alzheimer’s pathology in other ways

Anesthesia blocks sensation by cutting off communication within the cortex

November 8, 2023
Research Findings
Under propofol general anesthesia, sensory input still reaches the brain, but signals do not spread. Results suggest consciousness requires cortical regions to all be “on the same page.”

Anesthesia technology precisely controls unconsciousness in animal tests

October 31, 2023
Research Findings
An advanced closed-loop anesthesia delivery system that monitors brain state to tailor propofol dose and achieve exactly the desired level of unconsciousness could reduce post-op side effects

Decoding the complexity of Alzheimer’s disease

September 28, 2023
Research Findings
By analyzing epigenomic and gene expression changes that occur in Alzheimer’s disease, researchers identify cellular pathways that could become new drug targets

Individual neurons mix multiple RNA edits of key synapse protein, fly study finds

September 18, 2023
Research Findings
Neurons stochastically generated up to eight different versions of a protein regulating neurotransmitter release, which could vary how they communicate with other cells

The Sleeping Brain

September 14, 2023
Neural activity during sleep has a signature structure that the brain uses to make profound improvements in our thinking and wellness