Systems Neuroscience

Picower Institute scientists seek to understand the complex circuits and processes that the brain constructs and employs so that we can perceive, learn, think, plan, and feel. To learn more about these or other areas of inquiry, select them under Research Topics and you'll find relevant Picower people, discoveries and events.

Neurons are fickle. Electric fields are more reliable for information.

March 14, 2022
Research Findings
A new study suggests that electric fields may represent information held in working memory, allowing the brain to overcome “representational drift,” or the inconsistent participation of individual neurons

The model remodeler

March 14, 2022
Research Feature
A Picower Institute primer on ‘plasticity,’ the brain’s amazing ability to constantly adapt to and learn from experience

Feast or forage: Study finds circuit that helps a brain decide

November 22, 2021
Research Findings
By integrating multiple sensory inputs, a loop of mutual inhibition among a small set of neurons allows worms to switch between long-lasting behavioral states

Symposium spotlights crucial roles of dendrites

October 18, 2021
Recent Events
Scholars from around the world gathered online to share new research on how intricately structured neural processes enable plasticity of circuit connections and help integrate incoming information to enable brain function

'What Were you Thinking?'

September 20, 2021
Research Feature
How brain circuits integrate many sources of context to flexibly guide behavior

Behind the scenes, brain circuit ensures vision remains reliable

September 8, 2021
As mice watched movies, scientists watched their brains to see how vision could be represented reliably. The answer is that consistency in representation is governed by a circuit of inhibitory neurons

Novel approach reverses amblyopia in animals

September 1, 2021
Research Findings
By temporarily suspending retinal activity in the non-amblyopic eye of animal models, neuroscientists restrengthened the visual response in the amblyopic eye, even at ages after the critical period when patch therapy fails

Brain’s ‘memory center’ needed to recognize image sequences but not single sights

July 26, 2021
Research Findings
The visual cortex stores and remembers individual images, but when they are grouped into a sequence, mice can’t recognize that without guidance from the hippocampus

Grant to help scientists test whether brain region is a key locus of learning

July 23, 2021
New Research
Long thought of as a generic alarm system, the locus coeruleus may actually be a sophisticated regulator of learning and behavior, an MIT team posits

Bear earns amblyopia research award

June 28, 2021
Picower People
RPB Walt and Lilly Disney Award will support efforts to develop new therapeutic approach

As novel sights become familiar, different brain rhythms, neurons take over

June 8, 2021
Research Findings
As ‘visual recognition memory’ emerges in visual cortex, one circuit of inhibitory neurons supplants another and slower neural oscillations prevail

Mice naturally engage in physical distancing, study finds

March 31, 2021
Research Findings
MIT neuroscientists have identified a brain circuit that stops mice from mating with others that appear to be sick