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THE PICOWER INSTITUTE

Massachusetts Institute of Technology
43 Vassar Street, Bldg. 46-1303
Cambridge, MA 02139
(+1) 617-324-0305
(+1) 617-452-2588

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Disorders

Alzheimer's Disease
Anxiety Disorders
Autism Spectrum Disorders
Down Syndrome
Early Life Stress
Huntington's Disease
Mood Disorders
Parkinson's disease
Schizophrenia

Cognition and Motivation

Sleep
Motivation and Behavior
Learning and Memory
Higher Level Cognition
Arousal Control

Systems Neuroscience

Computational Neuroscience
Executive Function
Memory Systems
Neural Circuits
Neuromodulators
Oscillations
Reward Systems
Visual System

Molecular and Cellular

Glia
Neural Plasticity
Neural Signal Processing
Neuro Genomics and Proteomics
Synapse Mapping

Neurotechnology

Activity Sensors
Brain Imaging
Brain Stimulation
Genetic Engineering
Optogenetics
Tissue Processing

NSF ‘CAREER’ award helps fund Flavell lab study of behavioral states

Steve Flavell looks up from a microscope in his lab and smiles

February 12, 2019

Picower People

NSF ‘CAREER’ award helps fund Flavell lab study of behavioral states

Research will probe how states like sleep emerge and are sustained

Nedivi named to new professorship

Elly Nedivi looks at the camera before a backgrond of flasks and bottles on shelves in her lab

February 7, 2019

Picower People

Nedivi named to new professorship

Elly Nedivi is the inaugural William R. (1964) & Linda R. Young Professor of Neuroscience

Tsai earns Hans Wigzell Research Foundation Science Prize

Li-Huei Tsai and Hans Wigzell talk at the front of a lecture room as an audience watches

January 23, 2019

Picower People

Tsai earns Hans Wigzell Research Foundation Science Prize

Award recognizes Alzheimer's disease research

Mapping the brain at high resolution

Individually traced dopaminergic neurons in the right hemisphere of a fruit fly brain, innervating the fan-shaped body (green), ellipsoid body (magenta), and noduli (green).

January 17, 2019

Research findings

Mapping the brain at high resolution

New 3-D imaging technique can reveal, much more quickly than other methods, how neurons connect throughout the brain

Study finds the circuits that may help you keep your cool

Confocal microscopy image of the locus coeruleus region of the mouse brain displaying noradrenergic neurons in red and GABAergic neurons in cyan. A noradrenergic neuron recorded in the study is highlighted in white

January 14, 2019

Research findings

Study finds the circuits that may help you keep your cool

Prefrontal cortex may be able to regulate arousal in locus coreuleus

Scope advance reveals first look through all cortical layers of awake brain

Three-dimensional rendering of a sequence of 450 lateral three-photon images acquired with 2-μm increment from the visual cortex (layer 1 on the left to the subplate on the right). Green color represents GCaMP6s signal, and magenta color represents label free THG signal generated in the blood vessels and myelin fibers in the white matter.

January 11, 2019

Research findings

Scope advance reveals first look through all cortical layers of awake brain

Refinement of three-photon microscopy allows unprecendented neuroscience

Study shows how specific gene variants may raise bipolar disorder risk

In this data visualization, each horizontal line is a patient. Those with bipolar disorder were more likely to be on the lower end of the CPG2 protein expression scale, and more likely to have gene variants that reduced expression

January 9, 2019

Research findings

Study shows how specific gene variants may raise bipolar disorder risk

Findings could help inform new therapies, improve diagnosis

Chung leads collaboration to make the best brain map yet

A 2mm thick slice of human brain, treated with SHIELD, lays above some gridded paper so one can see that while yellowish, it is indeed translucent

January 2, 2019

News Feature

Chung leads collaboration to make the best brain map yet

Project will reveal the entire human brain, down to subcellular features

Gut-brain connection signals worms to alter behavior while eating

Two nematode worms, glowing light blue, swim over a black background

December 20, 2018

Research findings

Gut-brain connection signals worms to alter behavior while eating

Study may lead to a better understanding of the digestive tract’s nervous system

Mapping the brain, cell by cell, with SHIELD

In the globus pallidus externa neurons that express a protein called parvalbumin are labeled in red, and neurons labeled blue express a protein called GAD1.

December 17, 2018

Research findings

Mapping the brain, cell by cell, with SHIELD

Technique for preserving tissue allows researchers to create maps of neural circuits with single-cell resolution

How returning to a prior context briefly heightens memory recall

A hippocampus section featuring logn arcs stained blue (as a nuclear marker) and red to indicate the potassium ion channels key to the study

December 11, 2018

Research findings

How returning to a prior context briefly heightens memory recall

Going back to a scene makes engram cells more electrically excitable

Brown wins 2018 Dickson Prize in Science

Emery Brown poses on a stairwell before a yellow accent wall.

December 5, 2018

Picower People

Brown wins 2018 Dickson Prize in Science

CMU award recognizes 'physician-scientist'

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Massachusetts Institute of Technology
43 Vassar Street, Bldg. 46-1303
Cambridge, MA 02139
(+1) 617-324-0305
(+1) 617-452-2588

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From: https://picower.mit.edu/news/research-topics