“She has profoundly changed the field of neuroscience both by initiating a new circuit-based approach to study how the brain works and by bringing to light an entirely new thinking on how the brain processes emotional value,” says Li-Huei Tsai, director of the Picower Institute for Learning and Memory. “Her vision is original, innovative, and transformative.”
Tye’s laboratory uses several advanced techniques to interrogate brain circuitry underlying emotions. More specifically, her group synthesizes electrophysiology, pharmacology, microscopy, behavioral training, and optogenetics to finely tease out the networks that specifically relate to positive and negative emotional states, also known as valence.
“Kay’s dedication to studying how emotional and motivational associations get assigned to environmental cues and in identifying the specific neuronal circuits that process this information and their divergence points to encode positive and negative valence, promises to provide important mechanistic insight into our understanding … [of] psychiatric disorders,” says James DiCarlo, head of the MIT Department of Brain and Cognitive Sciences.
The specific circuit that Tye studies includes (but is not limited to) the dopaminergic system and the amygdala. Although dopamine has historically been viewed as a neurotransmitter responsible for attributing positive valence to experiences, her lab has clearly shown that it is also important for negative valence. Conversely, her work shows that the amygdala — a region primarily studied in the storage and recall of negative experiences — plays a critical role in attributing positive valance to experiences.
“Understanding how the brain processes valence is fundamental to understanding the numerous disease states related to anxiety, depression, addiction, feeding, social interaction, and learning and memory” Tye says.
In directly relating neural circuitry to emotional processing Tye’s work threads multiple dimensions of neuroscience, from molecules to complex behavior, and overcomes some of the limitations of correlational work. “The Young Investigator Award is a huge honor because it includes all fields of neuroscience and I am very grateful for this recognition,” Tye says.