(Tuesday) 4:00 pm - 5:00 pm
43 Vassar ST Room 46-3310, Cambridge, MA 02139
Most clinical-pathology studies Alzheimer¹s disease (AD) relate post-mortem findings to clinical diagnosis. However, the outcome of most therapeutic trials is cognitive decline. Few studies are positioned to relate post-mortem findings to change in cognition over multiple years prior to death. This presentation will introduce two community-based cohort studies of aging and AD in which all participants are organ donors. It will show that AD and other common brain pathologies to account for less than half of the person-specific variability of cognitive change over multiple years prior to death. It will highlight other pathologies and resilience markers associated with cognitive decline. It will show that many risk factors for AD dementia are associated with cognitive decline but not directly associated with any type of pathology or resilience marker identified to date. Finally, it will introduce a high dimensional brain omics pipeline that aims to identify additional proteins associated with cognitive decline and multiple neuropathologies, to nominate genes (proteins) as novel therapeutic targets.
Dr. David A. Bennett is the Director of the Rush Alzheimer’s Disease Center and the Robert C. Borwell Professor of Neurological Sciences at Rush University Medical Center in Chicago. He is principal of several grants from the NIH includin the Alzheimer’s Disease Core Center, including the Religious Orders Study and the Rush Memory and Aging Project. His pioneering analytic prospective clinical-pathologic cohort studies have linked a wide range of multi-level genomic data, experiential, psychological and medical risk factors to the development of AD and other common chronic conditions of aging. His studies include the investigation of peripheral blood biomarkers, ante- and post-mortem neuroimaging, biomedical devices, neuropathology and neurobiologic indices, as well as deep omics including epigenomics, transcriptomics, proteomics, and metabolomics that are now being used to feed the computational front end of drug discovery pipelines. He has about 600 peer-reviewed manuscript publications, with more than 58,500 citations and an h index=116.
The Picower Institute for Learning and Memory
Li-Huei Tsai, Ph. D.,
(Thursday) 8:30 am - 5:00 pm
43 Vassar ST Room 46-3002, Cambridge, MA 02139
“New Insights on Early Life Stress and Mental Health” is the focus of The Picower Institute 2016 Spring [...]
“New Insights on Early Life Stress and Mental Health” is the focus of The Picower Institute 2016 Spring Symposium scheduled for May 12, 2016. Early childhood adversity and its potentially lifelong debilitating effects is a global health crisis with repercussions including obesity, asthma, anxiety, addiction and depression. The symposium will feature experts presenting perspectives ranging from clinical practice to basic science.
|8:15 AM||Breakfast and Registration|
|9:00 AM||Opening Remarks
Rafael Reif, MIT President
Barbara Picower, President, JPB Foundation
|9:10 AM||Keynote Speaker
Jack Shonkoff – Harvard University
|9:50 AM||Nadine Burke Harris – Center for Youth Wellness|
|10:45 AM||Bruce McEwen – Rockefeller University|
|11:20 AM||John Gabrieli – Massachusetts Institute of Technology|
|11:55 AM||Fan Tait – American Academy of Pediatrics|
|1:30 PM||Kay Tye – Massachusetts Institute of Technology|
|2:05 PM||Ellen Perrin & Chris Sheldrick – Tufts Medical Center|
|3:00 PM||Darcy Lowell – Yale University School of Medicine|
|3:35 PM||Michael Lu – Health Resources and Services Administration|
|4:10 PM||Special Speaker
Geoffrey Canada – Harlem Children’s Zone
|4:50 PM||Session Closed|
Nadine Burke Harris founded Center for Youth Wellness, an organization that seeks to recognize and effectively treat toxic stress in children. Burke Harris and her organization address adverse childhood experiences as a risk factor for adult disease such as heart disease and cancer. Burke Harris also serves as an expert advisor on Hillary Clinton’s Too Small to Fail initiative, aiming to help parents and businesses improve the lives of children ages zero to five.
The accomplished doctor received a medical degree at UC Davis and a Masters in Public Health from Harvard. In 2005, she was called to work at the California Pacific Medical Center, where she developed programs to address health disparities in the San Francisco Bay Area. She noticed a gap in pediatric services especially, and pushed for better medical coverage. In 2007, she served as the founding physician and director of the Bayview Child Health Center, a pediatric clinic that provides children and teens with regular health services, regardless of their family’s ability to pay. It was there that she saw the greatest threat to many children’s health was their exposure to trauma and adversity.
Having worked with the Harlem Children’s Zone® for more than 30 years, Geoffrey Canada is renowned around the world for his pioneering work helping children and families in Harlem, and as a thought leader and passionate advocate for education reform.
From 1990 to 2014, Mr. Canada served as the President and Chief Executive Officer for the Harlem Children’s Zone, which The New York Times called “one of the most ambitious social-policy experiments of our time.” In 2011, Mr. Canada was named to the TIME 100 list of most influential people in the world and, in March 2014, was named one of Fortune’s 50 greatest leaders in the world. As of July 1, 2014, Mr. Canada stepped down as CEO, handing the reins to COO Anne Williams-Isom. He continues to serve as President of the HCZ and Promise Academy Boards.
Under Mr. Canada’s visionary leadership, HCZ has become a national model and the subject of significant media attention. Mr. Canada and HCZ have been featured in the documentary Waiting for “Superman,” as well as on 60 Minutes, The Oprah Winfrey Show, Anderson Cooper 360°, Black in America 2, The Charlie Rose Show, This American Life, and in articles in The Washington Post, The Wall Street Journal, Forbes, and The Associated Press. In 2008, Houghton Mifflin published Whatever It Takes, by Paul Tough, a detailed look at the work of Mr. Canada and HCZ.
John Gabrieli is the director of the Athinoula A. Martinos Imaging Center at the McGovern Institute. He is an Investigator at the Institute, with faculty appointments in the Department of Brain and Cognitive Sciences and the Harvard-MIT Division of Health Sciences and Technology, where is holds the Grover Hermann Professorship. He also co-directs the MIT Clinical Research Center and is Associate Director of the Athinoula A. Martinos Center for Biomedical Imaging, MGH/MIT, located at Massachusetts General Hospital. Prior joining MIT, he spent 14 years at Stanford University in the Department of Psychology and Neurosciences Program. Since 1990, he has served as Visiting Professor, Department of Neurological Sciences, Rush-Presbyterian-St. Luke’s Hospital and Rush Medical College. He received a Ph.D. in Behavioral Neuroscience in the MIT Department of Brain and Cognitive Sciences in 1987 and B.A. in English from Yale University in 1978.
Darcy Lowell, MD is an Associate Clinical Professor in the Department of Pediatrics and Child Study Center at Yale University School of Medicine. She is founder and CEO of Child First, a home-based, two-generation intervention serving very vulnerable young children and families, with the goal of preventing serious emotional disturbance, developmental and learning problems, and abuse and neglect. In 2001, Child First was developed as an innovative model that translated emerging scientific evidence into practice. It specifically targeted adverse childhood experiences by simultaneously decreasing toxic stress through care coordination, while buffering the effects of trauma on the developing brain through psychotherapeutic intervention. Through building strong, nurturing, responsive caregiver-child relationships, promoting adult and child executive capacity, and connecting families with needed community-based resources, Child First helps children and families heal from the devastating effects of stress and trauma. Child First has been designated by HHS as one of the evidence-based home visiting models of the Maternal, Infant, and Early Childhood Home Visiting Program (MIECHV). Child First currently operates in Connecticut, Florida, and North Carolina. Replication has continued to demonstrate strong outcomes in child mental health, social skills, and language development; parental depression and stress; caregiver-child interaction; and connection to community-based services.
Dr. Lowell was a Fellow of the Yale University Robert Wood Johnson General Pediatrics Academic Development Program and Zero to Three. She was Director of the Greater Bridgeport Children with Special Health Care needs Program for 15 years before developing Child First. She has been an active member of numerous local, state, and national councils and collaborations, including clinical faculty of the Yale Zigler Center in Child Development and Social Policy, Senior Fellow of the Child Health and Development Institute of CT, member of the Harvard Center on the Developing Child’s Frontiers of Innovation, founding member of the National Home Visiting Model Alliance, and member of the Executive Committee of the CT Association for Infant Mental Health. She is committed to innovation that translates research to practice, policy development, and system change.
Michael C. Lu, M.D., M.S., M.P.H., was named associate administrator of maternal and child health of the Health Resources and Services Administration (HRSA) on November 3, 2011. HRSA is an agency of the U.S. Department of Health and Human Services.
The mission of the Maternal and Child Health Bureau (MCHB) is to provide leadership, in partnership with key stakeholders, to improve the physical and mental health, safety and well-being of mothers, children and families. Through its Title V program, MCHB serves 40 million women, infants, children, adolescents, and their families each year, Including fathers and children with special health care needs.
Dr. Lu joined HRSA from the University of California, Los Angeles Schools of Medicine and Public Health, where he was associate professor of obstetrics, gynecology and public health.
Dr. Lu brings years of experience in MCH research, practice, and policy to his post at HRSA. Prior to his appointment, Dr. Lu chaired the Secretary’s Advisory Committee on Infant Mortality. He has served on two Institute of Medicine (IOM) committees (Committee on Understanding Premature Birth and Assuring Healthy Outcomes, and Committee to Reexamine IOM Pregnancy Weight Guidelines), and the Centers for Disease Control and Prevention Select Panel on Preconception Care.
Bruce S. McEwen obtained his Ph.D. in Cell Biology in 1964 from The Rockefeller University. He is a member of the US National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences. He served as President of the Society for Neuroscience in 1997-98. As a neuroscientist and neuroendocrinologist, McEwen studies environmentally-regulated, variable gene expression in brain, mediated by circulating steroid hormones and endogenous neurotransmitters in relation to brain sexual differentiation and the actions of sex and stress hormones on the adult brain, in particular related to structural and functional plasticity via epigenetic mechanisms. His laboratory discovered adrenal steroid receptors in the hippocampus in 1968. His laboratory combines molecular, anatomical, pharmacological, physiological and behavioral methodologies and relates their findings to human clinical information. His current research focuses on stress effects on amygdala and prefrontal cortex, as well as hippocampus, and his laboratory also investigates sex hormone effects and sex differences in these brain regions involved in cognitive function and mood regulation. He served on the MacArthur Foundation Research Network on Socioeconomic Status and Health, in which he has helped to reformulate concepts and measurements related to stress and stress hormones in the context of human societies, which led to the concept of “allostatic load and overload” that describes the wear and tear on the body and brain from chronic stress and related life style behaviors that lead to dysregulation of physiological stress pathways that are normally protective. He is also a member of the National Council on the Developing Child which focuses on biological embedding of early life experiences and promoting healthy brain development. He is the co-author of a book with science writer, Elizabeth Lasley, for a lay audience called “The End of Stress as We Know It”, published in 2002, and “The Hostage Brain” with science writer, the late Harold M. Schmeck, Jr., published in 1994, both of which are now available as eBooks.
Ellen C. Perrin, MD is a professor of developmental-behavioral pediatrics at the Floating Hospital at Tufts Medical Center. She received her medical degree from Case Western Reserve University in 1968 and completed a residency in Pediatrics at Children’s Hospital in the District of Columbia. She did a fellowship in Behavioral Pediatrics and received an MA in Developmental Psychology at the University of Rochester.
Since then she has been on the academic faculties of Vanderbilt University Medical School, the University of Rochester School of Medicine, and the University of Massachusetts Medical School before coming to the Floating Hospital for Children in December 2000.
She has been actively involved with the American Academy of Pediatrics, the American Board of Pediatrics, the Ambulatory Pediatric Association and the Society for Developmental and Behavioral Pediatrics. She is Board-Certified in Developmental-Behavioral Pediatrics.
Her clinical and research interests include children’s understanding of illness concepts, the management of developmental and behavioral issues and chronic health problems in primary care, and children in non-traditional families. She and Dr. Chris Sheldrick developed the Survey of Wellbeing of Young Children (SWYC) in response to the growing interest in comprehensive monitoring of children’s development in primary care and other settings.
Dr. Chris Sheldrick is a research psychologist and an Associate Professor of Pediatrics at the Floating Hospital at Tufts University School of Medicine. He received his B.A. from Brown University and his Ph.D. in Clinical Psychology from Temple University, and has received further training through a KM1 fellowship on comparative effectiveness. Dr. Sheldrick’s research focusses on the science and practice of screening, spanning from instrument development to implementation and evaluation. Collaborating closely with Dr. Ellen Perrin, he developed the Survey of Wellbeing of Young Children (SWYC).
He is currently collaborating on several projects focused on advancing the science of screening, including one designed to test the comparative accuracy of several screening instruments for young children with developmental-behavioral problems and a second to reduce health disparities in the detection of autism through implementation of evidence-based screening in early intervention settings. Dr. Sheldrick’s future interests focus on harnessing innovative methodologies in healthcare engineering to improve the overall effectiveness of screening procedures in pediatrics.
Jack P. Shonkoff, M.D., is the Julius B. Richmond FAMRI Professor of Child Health and Development at the Harvard T.H. Chan School of Public Health and Harvard Graduate School of Education; Professor of Pediatrics at Harvard Medical School and Boston Children’s Hospital; and Founding Director of the university-wide Center on the Developing Child at Harvard University. He currently serves as chair of the National Scientific Council on the Developing Child, a group of distinguished scholars whose mission is to bring credible science to bear on public policy affecting young children, and chairs the JPB Research Network on Toxic Stress, which is developing new knowledge and measurement capacity to assess the biological, bio-behavioral, and health consequences of excessive stress system activation. In 2011, he launched Frontiers of Innovation, a multi-sectoral collaboration among researchers, practitioners, policymakers, community leaders, parents, investors, and experts in systems change who are committed to achieving breakthrough outcomes for young children facing adversity.
Dr. Shonkoff has received multiple professional honors, including elected membership to the Institute of Medicine (now the National Academy of Medicine), the C. Anderson Aldrich Award in Child Development from the American Academy of Pediatrics, and the Distinguished Contributions to Social Policy Award from the Society for Research in Child Development. He served as Chair of the Board on Children, Youth, and Families at the National Academy of Sciences and led a blue-ribbon committee that produced the landmark report, From Neurons to Neighborhoods: The Science of Early Childhood Development. He has authored more than 150 publications, including nine books and monographs.
V. Fan Tait MD, FAAP is a pediatric neurologist, an Associate Executive Director of the American Academy of Pediatrics (AAP), and Director of the Department of Community and Specialty Pediatrics at the AAP. This Department includes five divisions: Children with Special Needs; Technical and Medical Services; Safety and Health Promotion; Hospital and Surgical Services; and Developmental Pediatrics and Preventive Services. Some of the AAP initiatives within the department include the National Center of Medical Home Initiatives; Bright Futures Guidelines for Healthy Supervision of Infants, Children and Adolescents; the AAP Julius B. Richmond Center of Excellence for Protecting Children from Secondhand Smoke; and the Red Book: Report of the Committee on Infectious Diseases. The majority of AAP Committees, Sections, and Councils are also housed within Dr. Tait’s department, including the Section on Genetics and Birth Defects and Committee on Genetics.
Prior to her move to the national AAP, Dr Tait was Associate Professor of Pediatrics at the University of Utah Health Sciences Center and Bureau Director of Children with Special Health Care Needs (CSHCN) for the Utah Department of Health. She served as a Pediatric Neurologist and medical director of neurorehabilitation at Primary Children’s Medical Center and the University of Utah Medical Center for 15 years. As Bureau Director for CSHCN she was responsible for 9 statewide programs including 3 direct clinical programs; population screening programs, such as newborn blood screening, newborn hearing screening, and birth defects registry and surveillance; case management programs for target populations of children who were technologydependent or in foster care; and Early Intervention.
As Bureau Director of CSHCN, Dr Tait served on numerous state and national advisory boards, committees and expert panels. She was principal investigator or co-principal investigator on several system-change grants including the Utah Medical Home Collaborative Project, the Utah Leadership Education in Neurodevelopmental Disabilities Grant, and the Utah Traumatic Brain Injury Planning Grant. Dr Tait was active in the Utah Chapter of the AAP, having served as vice president, president, and legislative chair. Nationally, she served as a member of the AAP Committee on State Government Affairs and as chair of the Taskforce on Newborn Hearing.
Kay Tye completed her undergraduate studies at MIT in 2003, majoring in Brain and Cognitive Sciences with a minor in Biology. She went to the University of California at San Francisco for her graduate studies under the mentorship of Patricia Janak to train in in vivo electrophysiology and behavioral neuroscience, and earned her PhD in 2008. Her thesis work was supported by a National Science Foundation Fellowship and was recognized with the Weintraub Award and the Lindsley Prize. She then stayed on for an extra year to complete a collaboration examining learning-induced plasticity using whole-cell patch-clamp recordings in acute slice preparations with Antonello Bonci. She then began her post-doctoral training at Stanford University in 2009 with the support of a National Research Service Award from the National Institute of Health under the mentorship of Karl Deisseroth, where she integrated her existing skill set with imaging and optogenetic techniques to examine the basis of motivated behaviors. She will now be returning to MIT to start her own lab as an assistant professor in Brain and Cognitive Sciences and the Picower Institute of Learning and Memory in January 2012.
The Picower Institute for Learning and Memory
Dr. Li-Huei Tsai
(Monday) 1:00 pm - 2:00 pm
43 Vassar ST Room 46-6309, Cambridge, MA 02139
This workshop is suitable for postdocs and graduate students who would like to learn the basics of R scripting to analyze /visualize RNA-Seq and ChIP-Seq data. Prior knowledge of RNA-Seq / ChIP-Seq is needed to participate in this workshop. The workshop will consist of a short lecture followed by demonstrations.
In the workshop, we will walk through some R commands from RNA-Seq QC, hierarchical clustering, PCA analysis, heatmap/boxplot generation to ChIP-Seq data visualization. We will use some publicly available RNA-Seq and ChIP-Seq data for the demo.
Please note that the workshop will last for 1 hour, and all the participants are recommended to download and install R software on their laptops for hands-on practice.
Fan Gao, Ph.D., The Picower Institute for Learning and Memory at MIT
Fan is a staff bioinformatician with PILM. Before moving to MIT, Fan was working as a research associate at University of Southern California, with a joint appointment at Zilkha Neurogenetic Institute and Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research.
The Picower Institute for Learning and Memory
Kenny JD, Taylor NE, Brown EN, Solt K. PLoS One. 2015 Jul 6;10(7):e0131914. doi: 10.1371