Three views of an organoid cell culture show the constiuent cells of the vaguely round, tangled mass of cells.  In the different views the cells are highlighted in different colors such as magenta and green.
April 14, 2026
Rett syndrome study highlights potential for personalized treatments
A video screenshot shows a grayscale worm twisting its body around in a loop to change direction
April 10, 2026
With navigating nematodes, scientists map out how brains implement behaviors
A member of a surgical staff holds a mask on the face of an unconscious patient in an operating room
March 17, 2026
Three anesthesia drugs all have the same effect in the brain, MIT researchers find
Li-Huei Tsai stands at a podium embossed with an MIT logo. In the foreground is an attentive audience. In the background is the Picower Institute logo
March 11, 2026
After 16+ years leading Picower Institute, Li-Huei Tsai will sharpen focus on research, teaching
Two panels show blue cells surrounded by thin green outlines. The outlines are much more consistent and prevalent in the image on the left, which is labeled as the wild type, than on the right which is labeled Rett syndrome.
February 25, 2026
In Rett syndrome, leaky brain blood vessels traced to microRNA

Alana Down Syndrome Center symposium highlights studies from brain to heart

April 14, 2026
Picower Events
Seven researchers from MIT, Rutgers University and the University of São Paulo shared the research they are doing to help people with trisomy 21 throughout their lifespan.

Rett syndrome study highlights potential for personalized treatments

April 14, 2026
Research Findings
Using advanced human cell cultures to model Rett syndrome, MIT researchers tracked how two different mutations alter neural circuit development and how each could be addressed with distinct potential therapeutics

A complete rethinking of how our brains use categories to make sense of the world

April 13, 2026
Research Findings
Challenging the classic view, two cognitive scientists argue in a new review that categorization is not a late, specialized stage of sensory processing. Instead, it is a core function operating at every level, anticipating bodily needs and motor plans.

With navigating nematodes, scientists map out how brains implement behaviors

April 10, 2026
Research Findings
How do nervous systems produce behaviors? A new MIT study provides a detailed mechanistic mapping of exactly what happens in the brains of C. elegans worms when they “follow their nose” to savor attractive odors or avoid unappealing ones

Leading with rigor, kindness, and care

April 2, 2026
Picower People
“We cannot be effective scientists if we are unhappy or unhealthy outside of the lab,” says “Committed to Caring” honoree Sara Prescott.

Brain Simulation

March 23, 2026
Research Feature
Picower Institute researchers and collaborators are inventing versatile new models of the brain to accelerate neuroscience discoveries and biomedical advances.

Three anesthesia drugs all have the same effect in the brain, MIT researchers find

March 17, 2026
Research Findings
Discovering this common mechanism could lead to a universal anesthesia-delivery system to monitor patients more effectively.

After 16+ years leading Picower Institute, Li-Huei Tsai will sharpen focus on research, teaching

March 11, 2026
Picower People
Tsai, who has grown the MIT neuroscience institute, will increase focus on research including Alzheimer’s disease and Down syndrome

In Rett syndrome, leaky brain blood vessels traced to microRNA

February 25, 2026
Research Findings
MIT neuroscientists have found that either of two genetic mutations that cause Rett syndrome undermine the structural integrity of developing blood vessels. By showing that the problem derives from overexpression of a microRNA, the new study points to a p

As worms and jellyfish wriggle, new AI tools track their neurons

February 24, 2026
Research Findings
Three new neural network-based tools enable fast, accurate alignment and annotation of images even in very wiggly subjects. The tools might offer a way to automate cell tracking in other imaging datasets, too.

Sloan Fellowship will help Fan advance technology to study how brain circuits change amid learning

February 17, 2026
Picower People
Linlin Fan uses innovative optical tools to precisely investigate how connections change among neurons during memory formation. With Sloan Foundation support, she plans to give the technology a significant upgrade

Fragile X study uncovers brainwave biomarker bridging humans and mice

February 11, 2026
Research Findings
A collaboration centered at MIT discovered that mice modeling the autism spectrum disorder fragile X syndrome exhibit the same pattern of differences in low-frequency waves as human patients, identifying a new biomarker for treatment studies