Assistant Professor of Neuroscience Kwanghun Chung

Kwanghun Chung

Assistant Professor of Chemical Engineering and Neuroscience
The Picower Institute for Learning and Memory
Institute for Medical Engineering and Science
Department of Chemical Engineering
Massachusetts Institute of Technology

Contact Info

Office: 46-5235
Phone: 617-452-2263

Administrative Assistant

Grace Gist
Office: 46-5235
Phone: 617-253-0009

The Chung Lab is an interdisciplinary research team devoted to developing and applying novel technologies for holistic understanding of large-scale complex biological systems. Specifically, we develop a host of methods including CLARITY (Nature, 2013), SWITCH (Cell, 2015), stochastic electrotransport (PNAS, 2015), MAP (Nature Biotechnology, 2016) that may enable identification of multi-scale functional networks and interrogation of their system-wide, multifactorial interactions. We are applying these technologies for studying brain function and dysfunction using animal models, human clinical samples, and organoid systems.

Kwanghun Chung is currently the Samuel A. Goldblith Career Development Assistant Professor of Chemical Engineering at MIT, as well as a Core Member of the Institute for Medical Engineering and Science (IMES). He is also a Core Member of the Picower Institute for Learning and Memory, and an Associate Member of the Broad Institute. He received his B.S. in Chemical Engineering from Seoul National University in 2005, and then moved to Georgia Institute of Technology for his Ph.D. training under the mentorship of Dr. Hang Lu, where he developed automated and integrated microsystems for high-throughput imaging, molecular/behavioral phenotyping, and cell microsurgery of a broad range of living systems. Following his graduation in 2009, Dr. Chung joined the Karl Deisseroth Lab at Stanford University for post-doctoral training in 2010, where he invented a novel technology termed CLARITY, which enables system-wide structural and molecular analysis of large-scale intact biological samples. In 2013, Dr. Chung established his independent group at MIT and has been leading an interdisciplinary team to develop and apply novel technologies for holistic understanding of large-scale complex biological systems. Chung was the recipient of the Mcknight Technological Innovations in Neuroscience Award 2016, the Packard Fellowships for Science and Engineering Award 2015, the NARSAD Young Investigator Award 2015, the Yumin Awards for Creativity 2014, the Searle Scholars Award 2014, and the BWF Career Award at the Scientific Interface 2012. 

  • Burroughs Wellcome Fund Career Awards at the Scientific Interface($500,000 over five years)
  • Ziegler Award for Best Research Paper
  • Anne Robinson Clough Conference Grant
  • James T. Porter Fellowship
  • Outstanding Performance on the Written Qualifying Exam
Featured publications are below. For a full list visit the lab website linked above.

July 25, 2016
Taeyun Ku, Justin Swaney, Jeong-Yoon Park, Alexander Albanese, Evan Murray, Jae Hun Cho, Young-Gyun Park, Vamsi Mangena, Jiapei Chen, and Kwanghun Chung. Nature Biotechnology, 2016, 34(9), 973-81.
December 3, 2015
Evan Murray, Jae Hun Cho, Daniel Goodwin, Taeyun Ku, Justin Swaney, Sung-Yon Kim, Heejin Choi, Jeong-Yoon Park, Austin Hubbert, Meg McCue, Young-Gyun Park, Sara Vassallo, Naveed Bakh, Matthew Frosch,, Van J. Wedeen, H. Sebastian Seung, and Kwanghun Chung. Cell, Dec 3:163(6): 1500-14.
November 17, 2015
Sung-Yon Kim, Jae Hun Cho, Evan Murray, Naveed Bakh, Heejin Choi, Kimberly Ohn, Sara Vassallo, Luzdary Ruelas, Austin Hubbert, Meg McCue, Philipp Keller and Kwanghun Chung. PNAS, 2015 Nov 17: 112(46): E6274-83.
May 30, 2015
Kwanghun Chung*, Karl Deisseroth*, Nature Methods, 2013, 10, 508-513 (*co-correspondence)
May 16, 2013
Kwanghun Chung, Jenelle Wallace, Sung-Yon Kim, Sandhiya Kalyanasundaram, Aaron Andalman, Tom J. Davidson, Kelly A. Zalocusky, Joanna Mattis, Sally Pak, Viviana Gradinaru, Hannah Bernstein, Julie Mirzabekov, Charu Ramakrishnan, and Karl Deisseroth, Nature, 2013, 497, 332-337

Brain wave stimulation may improve Alzheimer’s symptoms

March 14, 2019
Research findings
Noninvasive treatment can improve Alzheimer’s symptoms such as memory loss and amyloid plaque buildup in mice.

Chung leads collaboration to make the best brain map yet

January 2, 2019
News Feature
Project will reveal the entire human brain, down to subcellular features

Mapping the brain, cell by cell, with SHIELD

December 17, 2018
Research findings
Technique for preserving tissue allows researchers to create maps of neural circuits with single-cell resolution

Dozens from Picower present research at SfN

November 13, 2018
Recent Events
Researchers take part in field's largest annual exchange of ideas

Innovations giving neuroscientists exciting new ways to gain insights, symposium speakers say

October 25, 2018
Recent Events
Experts show advances in microscopy, tissue engineering, reporters of brain activity

Kwanghun Chung receives NIH New Innovator Award

October 13, 2016
Award will support the development of technologies that can enable a better understanding of complex biological systems.

Imaging the brain at multiple size scales

July 25, 2016
New technique can reveal subcellular details and long-range connections.

Heejin Choi
Postdoctoral Fellow

Margaret Grace McCue    

Evan Murray    
Research Affiliate


Massachusetts Institute of Technology
43 Vassar Street, Bldg. 46-1303
Cambridge, MA 02139
(+1) 617-324-0305
(+1) 617-452-2588