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… neurodegeneration microglia astrocytes epigenetics chromatin Single Cell Transcriptomics and Epigenomics … a key finding of "compromised compartmentalization": Chromatin that was locking genes down in health became more open in Alzheimer's, while chromatin that was open became more locked down. “For …

… control the encoding and retrieval of memories epigenetics chromatin engram hippocampus … process is controlled by large-scale remodeling of cells’ chromatin. This remodeling, which allows specific genes … several days. Changes to the density and arrangement of chromatin, a highly compressed structure consisting of DNA …

… around which DNA is spooled, forming a structure called chromatin. These modifications condense chromatin, making genes in that stretch of DNA less likely to … that a gene called Sp3 is necessary to recruit HDAC2 to chromatin to enact its blockade of memory-linked genes. The …

… innovations include inhibiting an enzyme that affects the chromatin structure of DNA to rescue gene expression and …

… at Stanford University, focusing on the role of the BAF chromatin remodeling complex during neural development. …

… for genome-wide analysis of enhancers and elucidated the chromatin features of these regulatory sequences. He is a …