Using optogenetic, pharmacological, electrophysiological, and imaging techniques, Tye's laboratory interrogates brain circuitry to elucidate pathways implicated in anxiety disorders, which represent the most common form of psychiatric illnesses. “Anxiety can be thought of as a pathological imbalance in the motivation to avoid anticipated threats relative to the motivation to seek out potential rewards,” says Tye. Such imbalances are likely a result of imbalances in excitation and inhibition in specific brain circuits.
Pharmacological therapies to treat anxiety disorders, which are moderately effective and have potentially harmful side effects, cannot discriminate between particular brain pathways. In using optogenetics along with other techniques, her lab can identify specific brain circuits with exceptional precision. We “will hopefully facilitate the development of treatments that are more efficacious and have fewer side effects,” says Tye.
“The NARSAD Young Investigator award was critical in helping me launch my career as an independent investigator, allowing us to pursue research on the neural circuitry underlying behaviors relevant to mental illnesses,” says Tye.
“These prizes bestowed annually recognize young researchers whose work in child and adolescent depression, anxiety, unipolar and bipolar depression, and schizophrenia further advance the quest to identify the biological roots of mental illness,” says Jeffrey Borenstein, president and CEO of the Brain and Behavior Research Foundation.
Winners of the Klerman and Freedman Prizes were selected by the Foundation’s Scientific Council, comprising experts across disciplines in brain and behavior research including Nobel Prize winners, former directors of the National Institute of Mental Health, recipients of the National Medal of Science, and members of the National Academy of Sciences.