Join us for a joint Alana Down Syndrome Center (ADSC) and Aging Brain Initiative (ABI) symposium on October 5-6, 2022. The ABI and the ADSC have joined forces for this year's symposium to highlight how aging-related changes to the brain overlap with neurological aspects of Down syndrome. Our hope is to encourage greater collaboration between the brain aging and Down syndrome research communities. The topic this year will be Glial and Neuronal Biology of the Aging Brain.
This event will take place virtually over the course of two days: October 5 and October 6. Talks will begin at 1:00pm ET on October 5 and 9:00am ET on October 6 . The October 6 talks will be followed by a virtual poster session beginning at 12:15pm ET. Please find the complete agenda below.
About ABI and ADSC
The event is entirely virtual and can be viewed via webcast.
- All registrants will be sent the webcast link via email one week prior to the event (with reminders the day prior and morning of the event). Please keep in mind that emails will be sent to the email address you use to register.
Wednesday, October 5 | Moderator: Ravikiran Raju, Picower Institute, MIT, Boston Children's Hospital
- 1:00-1:10pm: Opening Remarks, Li-Huei Tsai, Director, Picower Institute, MIT, Lead Investigator, Aging Brain Initiative, Director, Alana Down Syndrome Center
- 1:10-1:40pm: Beth Stevens, Boston Children's Hospital, Harvard Medical School, "Connecting Microglia States to Function in Health and Disease"
- 1:40-2:10pm: Li Gan, Weill Cornell Medical College
- 2:10-2:40pm: Michael Heneka, Luxembourg Centre for Systems Biomedicine (LCSB)
- 2:40-3:00pm: Break
- 3:00-3:30pm: Elizabeth Head, University of California, Irvine, "Cerebrovascular Pathology as a Function of Age and Alzheimer disease in Down syndrome"
- 3:30-4:00pm: Gilbert Di Paolo, Denali Therapeutics, "Lysosomal Functions of Progranulin and Implications for Treatment of Frontotemporal Dementia"
- 4:00-4:05pm: Closing Remarks, Emily Niederst, Director of Scientific Initiatives for the Alana Down Syndrome Center and the Aging Brain Initiative
Thursday, October 6 | Moderator: Jackie Yang, Research Scientist, Kellis Lab, MIT
- 9:00-9:10: Opening Remarks, Li-Huei Tsai, Director, Picower Institute, MIT, Lead Investigator, Aging Brain Initiative, Director, Alana Down Syndrome Center
- 9:10-9:40am: Nancy Yuk-Yu Ip, The Hong Kong University of Science and Technology, "Understanding Innate Immunity in Alzheimer's Disease – Insights for the Development of Therapeutics"
- 9:40-10:10am: Tracy Young-Pearse, Brigham and Women's Hospital, Harvard Medical School , "APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons"
- 10:10-10:40am: Shane Liddelow, NYU, "Reactive Astrocyte Responses to Inflammation and Neurodegeneration"
- 10:40-11:00am: Break
- 11:00-11:30am: Myriam Heiman, Picower Institute, MIT, "Single-cell Dissection of the Human Cerebrovasculature in Health and Disease"
- 11:30am-12:00pm: Adam M. Brickman, Columbia University, "White Matter Hyperintensities are a Core Feature of Alzheimer's Disease: Evidence from Late Onset and Genetic Forms"
- 12:00-12:05pm: Closing Remarks, Emily Niederst, Director of Scientific Initiatives for the Alana Down Syndrome Center and the Aging Brain Initiative
- 12:05-12:15pm: Break/Poster Session Set-up
- 12:15-1:15pm: Virtual Poster Session (held on Aimeet)