Aging Brain Initiative Symposium

Cellular & Molecular Mechanisms of Neurodegeneration

This conference will be held virtually. Click here to register.

We invite you to join us for the MIT Aging Brain Initiative's bi-annual symposium, Cellular & Molecular Mechanisms of Neurodegeneration, on September 22, 2020 from 9:00am - 5:00pm.

^{The Aging Brain Initiative is an ambitious interdisciplinary effort by MIT focusing on understanding neurodegeneration and efforts to find hallmarks of aging, both in health and disease. The Initiative is broad, made up of scientists in several areas, including systems neuroscience, cell biology, engineering and computational biology, with core investigators from the Departments of Biology, Brain & Cognitive Sciences, Biological Engineering, and Computer Science & Artificial Intelligence Labs.}

^{The theme of this symposium is “Cellular & Molecular Mechanisms of Neurodegeneration.”}

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Speakers:

David Attwell Valina Dawson
^{University College London Johns Hopkins University School of Medicine}

Anne Brunet Myriam Heiman
^{Stanford University MIT Picower Institute, Broad Institute}

Diane Chan Jonathan Kipnis
^{MIT Picower Institute Washington University in St. Louis, School of Medicine}

Don Cleveland Lennart Mucke
^{University of California, San Diego University of California, San Francisco}

Marco Colonna Dorothy Schafer
^{Washington University in St. Louis, School of Medicine University of Massachusetts Medical School}

Agenda:

Morning Session	Moderated by Li-Huei Tsai
9:00 - 9:05am	Opening Remarks, Li-Huei Tsai
9:05 - 9:35am	David Attwell, University College London	The role of capillary pericytes in early Alzheimer's disease
9:35 - 10:05am	Myriam Heiman, MIT Picower Institute, Broad Institute	Genome-wide in vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity
10:05 - 10:35am	Marco Colonna, Washington University in St. Louis, School of Medicine	Harnessing TREM2 in Alzheimer’s Disease
10:35 - 10:50am	Break
10:50 - 11:20am	Jonathan Kipnis, Washington University in St. Louis, School of Medicine	Meningeal lymphatics in aging and Alzheimer’s disease
11:20 - 11:50am	Dorothy Schafer, University of Massachusetts Medical School	Microglia-based mechanisms governing synapse loss in the inflamed brain
11:50am - 12:20pm	Panel Discussion
12:20 - 1:20pm	Lunch
Afternoon Session	Moderated by Li-Huei Tsai
1:20pm - 2:00pm	Keynote: Don Cleveland, University of California, San Diego	“Designer DNA drug” therapies for neurodegenerative disease
2:00 - 2:30pm	Valina Dawson, Johns Hopkins University School of Medicine	Modeling Sporadic Parkinson’s disease
2:30 - 2:45pm	Break
2:45 - 3:15pm	Diane Chan, MIT Picower Institute	Manipulating Gamma Frequency Neural Oscillations Using Sensory Stimulation to Treat Alzheimer’s Disease
3:15 - 3:45pm	Lennart Mucke, University of California, San Francisco	Tau: Enabler of Diverse Brain Disorders and Target of Rapidly Evolving Therapeutic Strategies
3:45 - 4:15pm	Anne Brunet, Stanford University	Mechanisms of brain aging and ‘rejuvenation'
4:15 - 4:45pm	Panel Discussion

This conference will be held virtually. Click here to register.

Host

Li-Huei Tsai

Organizer

Brittany Greenough