Cutting Edge Approaches to Studying the Aging Brain

The Aging Brain Initiative Fall 2023 Symposium

Join us in person or online on Monday, October 23 for a half day symposium by the Aging Brain Initiative at MIT, this year titled "Cutting Edge Approaches to Studying the Aging Brain." This year's annual symposium features researchers who are doing interdisciplinary work to bridge the biological research of brain aging with new technologies to study it. From computer science to gene therapy, the speakers will present the latest in cutting-edge approaches to study neurodegeneration. A trainee poster session and reception will follow the talks.

Registration is FREE but required for both in person and virtual attendance.

Please CLICK HERE to register and receive the link to watch online (you will receive the link even if you plan to attend in person).

This event will be held at The Picower Institute for Learning and Memory in MIT Building 46, located at 43 Vassar Street, Cambridge, MA 02139. Upon arrival, take any elevator or staircase to the THIRD FLOOR. Talks will be held in Singleton Auditorium (46-3002).

SCHEDULE

1:00-1:05pm	Opening Remarks: Li-Huei Tsai, Director, Picower Institute and Aging Brain Initiative
1:05-1:40pm	Peter Dedon, MIT Biological Engineering, The tRNA epitranscriptome, translational dysregulation, and neurodegenerative diseases
1:40-2:15pm	Ritu Raman, MIT Mechanical Engineering, Engineering the biological motor control system
2:15-2:50pm	Thomas Heldt, MIT Electrical Engineering & Computer Science, Tracking eye movement features across the age spectrum
2:50-3:05pm	Break
3:05-3:40pm	Ann Graybiel, MIT Brain and Cognitive Sciences, Engagement and the Aging Brain
3:40-4:30pm	Keynote: Maiken Nedergaard, University of Rochester Center for Translational Neuromedicine and Dept of Neurosurgery, The Glymphatic System
4:30-4:35pm	Closing Remarks: Emily Niederst, Strategic Director, Aging Brain Initiative
4:35-6:00pm	Reception and Trainee Poster Session

POSTER PRESENTERS

1	Cristina	Blanco Duque	Tsai Lab	The relevance of neuromodulation for the beneficial effects of 40Hz treatment on amyloid pathology
2	Nikita	Budnik	Pan Lab	Biophysical functional characterization of missense variants of voltage-gated calcium channel CaV2.1 (CACNA1A)
3	Kendyll	Burnell	Nedivi Lab	Developing methods for integrating multi-color structural and functional in-vivo 2-photon imaging
4	Diane	Chan	Tsai Lab	Long-term effects of induced gamma neural activity in patients with mild Alzheimer's disease
5	SeoWoo	Choi	Chung Lab	Effective preservation of biomolecules in large-scale non-perfusable tissues for spatial multi-omic analysis
6	Francisco	Garcia	Heiman Lab	Single-Cell Dissection of the Human Brain Vasculature
7	Lizzy	Joo	Feng Lab	Region- and cell-type-specific expression pattern of brain ADAR2 using epitope-tag knock-in mice
8	Byunguk (Brian)	Kang	Fraenkel Lab	Pooled, optical proteomic profiling platform to study Huntington's Disease pathways
9	Andrew	Kirjner	Fiete Lab	Enhancing membrane localization of Arch3-based GEVIs with ML-guided one-shot directed evolution
10	Jamie	Koerner	Heldt Lab	Recording Eye Movements on Mobile Devices
11	Alex	LeNail	Heiman Lab	Transcription Factor Gene Therapies to Reverse Neurodegeneration
12	Matthew	Leventhal	Fraenkel Lab	Network models elucidate contribution of genetic screens in model organisms to human Alzheimer’s disease
13	Ayano	Matsushima	Graybiel Lab	Huntington’s Disease Produces Multiplexed Transcriptional Vulnerabilities of Striatal D1-D2 and Striosome-Matrix Neurons
14	Connie	New	Fraenkel Lab	Longitudinal plasma metabolomics reveal subtypes of ALS progression
15	Juhyuk	Park	Chung Lab	A scalable tissue-hydrogel platform for multi-scale imaging and phenotyping of the human brain
16	Sebastian	Pineda	Heiman Lab	Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD
17	Chenxi	Qiu	Yankner Lab	An early molecular mechanism in Traumatic Brain Injury
18	Hugo	Ramirez	MEG Pantazis Lab	Fully Hyperbolic Neural Networks: A novel approach to discover aging trajectories from MEG brain networks
19	Daniela	Rodrigues Amorim	Tsai Lab	Multisensory gamma entrainment as a pro-remyelination and anti-neuroinflammatory therapeutic strategy in demyelinating diseases
20	Gregory	Thiabaud	Jasanoff Lab	Metallotexaphyrins: a versatile multimodal imaging platform for probing biomarkers in Alzheimer's Disease.
21	Yuxuan	Tian	Chung Lab	3D visualization of AD-associated pathology in thick brain tissues utilizing a multiplexed, scalable proteomic labeling pipeline
22	Stanislav	Tsitkov	Fraenkel Lab	Disease related changes in ATAC-Seq of more than 450 iPSC-derived motor neuron lines from ALS patients and controls
23	Matheus	Victor	Tsai Lab	Human Microglia State Dynamics in the Progression of Alzheimer's Disease
24	Shiwei	Wang	Boyden & Kiessling Labs	Heparan sulfate in human pluripotent stem cell
25	Shannon	Wright	Tsai Lab	A single-cell atlas of ABCA7 loss-of-function reveals lipid disruptions, mitochondrial dysfunction and DNA damage in neurons
26	Yu-Xin	Xu	Fraenkel Lab	Multi-omics analyses reveal overlapping impact of CAG repeat expansion and HTT knockout on Huntington’s Disease phenotypes from human pluripotent-derived cortical neurons

Host

Li-Huei Tsai

Organizer

Brittany Greenough