… Tsai has pioneered the use of human induced pluripotent stem cell (iPSC) models to understand how APOE4 adversely … “isogenic” lines of neuron, astrocyte and microglia brain cells, showed that ApoE4 changes lipid metabolism in … and the blood-brain barrier, her lab found that pericyte cells carrying ApoE4 increased ApoE protein expression, …
… she made the breakthrough discovery that radial glial cells are neural stemcells. This inspired her to attempt turning also adult … injury when she was appointed Director of the Institute of Stem Cell Research at the Helmholtz Center Munich in 2004 and …
… a lab at Columbia University. There he learned how neural stemcells become neurons and how the cellular environment helps … In one he plans to turn human induced pluripotent stemcells (IPSCs) into microglia, an immune cell of the …
… to culture cerebral organoids, or “minibrains,” using stemcells derived from people has given scientists experimentally … recognize and track architectural patterns formed by the cells as the organoids develop or are affected in models of …
… iPS Core Facility The advent of human induced pluripotent stemcells (iPSCs) has heralded a new generation of clinical and … into human disorders. Patient-derived skin fibroblast cells are reprogrammed into iPS cells, which allow …