… decided to explore the role of sirtuins in endothelial cells, which line the inside of blood vessels. To do that, … which encodes the major mammalian sirtuin, in endothelial cells of mice. They found that at 6 months of age, these mice … Vittorio Sartorelli, chief of the Laboratory of Muscle StemCells and Gene Regulation at the National Institute of …
… of Alzheimer’s disease, which affects many types of cells in the brain including its blood vessels, has proven … and validated such an in vitro BBB from patient-derived stemcells. Moreover, he made versions with the Alzheimer’s risk …
… from cognition to cancer The nervous system regulates stem and precursor cell behavior across a range of tissues. … of healthy glial progenitors, oligodendrocyte precursor cells (OPCs), and the consequent generation of new … of neuronal activity on normal oligodendroglial precursor cells, a putative cellular origin for many forms of glioma, …
… new insights into the nature of diseases that cause brain cells to die, but also described promising new treatment … potential treatment for Parkinson’s disease in which brain cells called astrocytes can be converted into neurons in a … mice, negatively impacting the proliferation of neural stemcells and therefore their ability to produce new neurons …
… / A26 Altered 3D-Genome Architecture of Neural Progenitor Cells as a Consequence of Down Syndrome *H. MEHARENA 1 , … York, NY Monday, Oct. 21, 2019 Session 278 Pluripotent StemCells and Organoid Models of Degenerative Diseases 10:00 AM - …
… more fundamental understanding of the biology going on in cells of people with Down syndrome, often also called trisomy … in the lab is by engineering human cell cultures from cells taken from patients. Skin cells, for instance, can be turned into stemcells, which in turn can grow into neurons or heart …
… how a genetic aberration undermines the function of brain cells and circuits . Learning how things go wrong puts within … survive the disease. The gene, as it turns out, may help cells dispose of protein a ggregates (such as mutant … vs. the more common APOE3 version. In 2018, they used stemcells derived from patients’ skin cells to create …