… Genes & plasticity in memory Memories form when cells connect … synapses, in response to experience is called “synaptic plasticity.” In several studies, including ones dating back a … 1992 Tonegawa’s lab demonstrated for the first time that genes for synaptic plasticity were crucial for memory. His …
… how chromatin physically locks down the expression of genes needed for promoting neural “plasticity,” the property needed to form new circuit … regulated neuronal expression of genes supporting synaptic plasticity, learning, and memory. HDAC2 was the target of the …
… HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions. This … These modifications control gene expression by blocking genes in certain stretches of DNA from being copied into RNA. … they also lost some of their ability to modulate synaptic plasticity — changes in the strength of the connections …
… mechanisms underlying activity-dependent synaptic plasticity.” Howard E. Shrobe , a principal research … Read more Award honors Elly Nedivi’s research on cortical plasticity November 6, 2023 Picower People Award honors Elly Nedivi’s research on cortical plasticity The Krieg Cortical Kudos Discoverer Award …
… to change and adapt with experience (a property known as plasticity) can also be sources of vulnerability to disease … called CPG2, encoded by the gene SYNE1, critically enables plasticity during health but significantly increases … showed up in screens Nedivi conducted as a postdoc to find genes and molecules that implement neural plasticity. Ever …
… of Rett Syndrome cases. Years of basic research on genes involved in synaptic plasticity led Mriganka Sur ’s lab to discover that in mouse … and circuit-specific problems in the maturation and plasticity of cortical neurons. The dysfunction, which …
… or synapses, to change with experience (a property called “plasticity”), the lab of Mriganka Sur, Newton Professor of … last year. The lab discovered the role of IGF1 in neural plasticity in 2006 when they showed that it critically … left open (a dramatic phenomenon called ocular dominance plasticity). In 2009 they revealed that IGF1 was also …
… leading to experience dependent changes in synaptic plasticity. Chloe Delepine Mriganka Sur Employing 3D cerebral … with a particular focus to study methods to modify neural plasticity in multiple sclerosis. Kyung-Seok Han Weifeng Xu … his research interests on how astrocytes affect synaptic plasticity in the learning and memory as well as addiction. …