… that activation of a metabotropic glutamate receptor (mGluR5) triggers new protein synthesis in neurons that causes … loss of FMRP. In 2007 the Bear Lab showed that reducing mGluR5 expression by 50 percent significantly reduced a wide … elucidated the molecular mechanisms underlying the role of mGluR5 overactivity in fragile X symptoms and in 2012 the lab …