March 03, 2021
Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk
… They then stimulated these cells to differentiate into astrocytes, the brain cells that produce the most APOE. APOE4 astrocytes showed dramatic changes in how they process lipids compared to APOE3. In APOE4 astrocytes, there was a significant buildup of neutral lipids …