… mice raised in the dark or with MD. A protein called IGF1 stood out. Artificially adding it prevented ODP. As they studied IGF1 more they realized that it promoted synaptic maturation … syndrome, and that giving Rett model mice doses of human IGF1 could help correct problems caused by the mutation not …
… to synaptic maturation comes via a protein called IGF1 that is reduced among people with Rett. That insight … them to show that treating Rett-model mice with extra IGF1 peptide or IGF1 corrected many defects of MECP2 mutation. Both treatment …
… paper in PNAS showing that doses of recombinant human IGF1 were effective in mice. And I was also the co-author in … come true! Research Article Rett syndrome , plasticity , IGF1 , neurodevelopmental disorders , MECP2 Print Share …