New research addresses a gap in understanding how ketamine’s impact on individual neurons leads to pervasive and profound changes in brain network function.

Many neurons exhibit “mixed selectivity.” They can integrate multiple inputs and participate in multiple computations. Mechanisms such as oscillations and neuromodulators recruit their participation and tune them to focus on the relevant information.

With support from The Marcus Foundation, an MIT neuroscientist and a Harvard Medical School immunologist will study the “fever effect” in an effort to devise therapies that mimic its beneficial effects.

Bursts of brain rhythms with “beta” frequencies control where and when neurons in the cortex process sensory information and plan responses. Studying these bursts would improve understanding of cognition and clinical disorders, researchers write.

Thought emerges and is controlled in the brain via the rhythmically and spatially coordinated activity of millions of neurons, scientists argue in a new article. Understanding cognition and its disorders requires studying it at that level.

Alana Down Syndrome Center team recruiting volunteers to test whether 40Hz light and sound stimulation produces cognitive benefits.

Scientists have now observed how the brain’s place cells stave off inhibitory input in the process of establishing their tuning to specific locations. The study shows that signaling by endocannabinoids is required.

Single-cell gene expression patterns in the brain’s motor and frontal cortex, and evidence from follow-up experiments, reveal many shared cellular and molecular similarities that could be targeted for potential treatment

To learn how the brain works, Picower Institute labs are advancing technologies and methods to watch it live as it happens

Stimulating gamma brain waves may protect cancer patients from memory impairment and other cognitive effects of chemotherapy, a new mouse study suggests.

Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer’s protein via the brain’s glymphatic system, new study suggests.

Across mammalian species, brain waves are slower in deep cortical layers, while superficial layers generate faster rhythms.