… and Cognitive Sciences faculty. “We see convergence of lipidmetabolism being disrupted, but when you really look into further detail at the kind of lipid pathways being disturbed in different brain cell types, …
… microglia contribute to Alzheimer’s disease A breakdown of lipidmetabolism in these brain cells promotes inflammation and … that if researchers could find a way to restore normal lipidmetabolism in microglia, that might help to treat some …
… one copy of the APOE4 gene. APOE is a protein involved in lipid transport. Studies show that the APOE4 variant is … pathway, which showed that APOE4-induced dysfunction of lipidmetabolism in neurons by cellular accumulation of unsaturated …
… version of the APOE gene, which is normally involved in metabolism and transport of fatty molecules such as … APOE4 astrocytes, the researchers found that cholesterol metabolism was highly dysregulated. The cells produced twice …
… and microglia brain cells, showed that ApoE4 changes lipidmetabolism in astrocytes, causes hyperactivity in neurons and … vein the lab demonstrated in 2021 that APOE4 disruption of lipidmetabolism in human iPSC-derived astrocytes could be …