May 16, 2022
Circuit model may explain how deep brain stimulation treats Parkinson’s disease symptoms
… called fast-spiking interneurons (FSIs) can produce gamma-frequency rhythms (30-100 Hz) that regulate the beta … MSNs, to other regions and then back to the STN. “The FSI gamma is important to keep the MSN beta in check,” Adam said. … more beta and the FSIs lose their ability to produce gamma to quench that beta, so the beta goes wild. The FSIs …