Disorders

Picower Institute scientists investigate the pathophysiological mechanisms underlying complex disorders of the brain that affect emotion and cognition. To learn more about research in these or other areas, select them under "Research Topics" and you'll find relevant Picower people, discoveries and events.

March 27, 2024

Picower Events

Alana Down Syndrome Center team recruiting volunteers to test whether 40Hz light and sound stimulation produces cognitive benefits.

February 28, 2024

Research Findings

Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer’s protein via the brain’s glymphatic system, new study suggests.

January 18, 2024

Research Findings

Across mammalian species, brain waves are slower in deep cortical layers, while superficial layers generate faster rhythms.

December 20, 2023

Research Feature

A new review surveys a broadening landscape of studies showing what’s known, and what remains to be found, about the therapeutic potential of non-invasive sensory, electrical or magnetic stimulation of gamma brain rhythms.

December 20, 2023

Research Feature

Picower Institute scientists are using single cell genomics techniques to measure gene expression and produce unque insights into nervous system biology and disease

December 11, 2023

Research Findings

In mice and human cell cultures, MIT researchers showed that novel nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s disease

November 16, 2023

Research Findings

A new MIT study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation and contribute to Alzheimer’s pathology in other ways

November 2, 2023

New Research

Picower Institute-based collaboration will study mechanisms that might enable peripheral immune cells to deliver a potentially therapeutic molecule to the brain.

November 1, 2023

Picower Events

Seed projects, posters represent a wide range of labs working on technologies, therapeutic strategies, and fundamental research to advance understanding of age-related neurodegenerative disease

October 30, 2023

Picower People

Society for Neuroscience Award recognizes Professor Mark Bear’s synaptic plasticity research, its translation to potential amblyopia and autism treatments, and his career of mentorship.

September 28, 2023

Research Findings

By analyzing epigenomic and gene expression changes that occur in Alzheimer’s disease, researchers identify cellular pathways that could become new drug targets

September 14, 2023

Neural activity during sleep has a signature structure that the brain uses to make profound improvements in our thinking and wellness

Tsai presents non-invasive stimulation study at Massachusetts Down Syndrome Congress

How sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice

Study reveals a universal pattern of brain wave frequencies

Evidence early, but emerging, that gamma rhythm stimulation can treat neurological disorders

'Cellf' Expression

Nanoparticle-delivered RNA reduces neuroinflammation in lab tests

How a mutation in microglia elevates Alzheimer’s risk

New grant to study possibility of an immunotherapy for autism

Aging Brain Initiative symposium showcases ‘cutting edge’ research across MIT

Mark Bear wins SfN’s Julius Axelrod Prize

Decoding the complexity of Alzheimer’s disease

The Sleeping Brain