How is the brain modified by experience, deprivation and disease?
Mark F. Bear received his Ph.D. in neurobiology from Brown University. He took postdoctoral training from Wolf Singer at the Max Planck Institute for Brain Research in Frankfurt, Germany, and from Leon Cooper at Brown. He joined the faculty of the Brown University School of Medicine in 1985 and was named a Howard Hughes Medical Investigator in 1996. At Brown, he was awarded the 2000 Elizabeth H. Leduc Award for teaching excellence in the life sciences, and the Class of 2000 Barrett Hazeltine Citation for teaching excellence. In 2003, he was appointed Picower Professor of Neuroscience at The Picower Institute for Learning and Memory in the Department of Brain and Cognitive Sciences at MIT.
Osterweil, E.K., Chuang, S-C., Chubykin, A.A., Sidorov, M., Bianchi, R., Wong, R.K.S., and Bear, M.F. 2013. Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome. Neuron 77(2): 243-250.
Osterweil, E.K., Krueger, D.D., Reinhold, K. and Bear, M.F. 2010. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. J. Neurosci. 30 (46): 15616-15627.
Krueger, D.D. and Bear, M.F. 2010. Toward fulfilling the promise of molecular medicine in fragile X syndrome. Annual Review of Medicine 62:4111-429.
Cooke, S.F. and Bear, M.F. 2010. Visual experience induces long-term potentition (LTP) in the primary visual cortex. J. Neurosci. 30(48): 16304-16313.
Krueger, D.D., Osterweil, E.K., Chen, SP, Tye, LD, and Bear, M.F. 2011. Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome. PNAS USA 108(6): 2587-2592.
Auerbach, B.D., Osterweil, E.K. and Bear, M.F. 2011. Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature 480(7375): 63-68.
Bhakar, A.L., Dölen, G., and Bear, M.F. 2012. The pathophysiology of fragile X (and what it teaches us about synapse). Annual Review of Neuroscience (epub ahead of print 5 April 2012).
Alfred P. Sloan Award
United States Office of Naval Research Young Investigator Award
Society for Neuroscience Young Investigator Award
Brown University Class of 2000 Barrett Hazeltine Citation for Teaching Excellence
William and Enid Rosen Award for Outstanding Contributions to Understanding Fragile X Syndrome, National Fragile X Foundation
Pioneer Award, FRAXA Research Foundation
Award for Outstanding Contributions to the Study of Metabotropic Glutamate Receptors, 7th International mGluR Meeting, Taormina, Italy
Ray Fuller Award, American Society for Pharmacology and Experimental Therapeutics