Earl Miller

Photo: Len Rubenstein
Neural Basis of Memory and Cognition

Interests in the Miller laboratory center around the neural mechanisms of attention, learning, and memory needed for voluntary, goal-directed behavior. Much effort is directed at the prefrontal cortex, a cortical region at the anterior end of the brain that is greatly enlarged in primates, especially humans. The prefrontal cortex has long been known to play a central role in cognition. Its damage or dysfunction disrupts the ability to ignore distractions, hold important information "in mind", plan behavior, and control impulses. The lab explores prefrontal function by employing a variety of techniques including multiple-electrode neurophysiology, psychophysics, pharmacological manipulations, and computational techniques.

Recent work in the lab has shown that neurons in the prefrontal cortex have complex properties that are ideal for a role in cognitive control. Their activity is highly dependent on, and shaped by, task demands. They are selectively activated by relevant sensory inputs, involved in recalling stored memories, and they integrate the diverse information needed for a common behavioral goal. Perhaps most importantly, they transmit acquired knowledge. Their activity reflects learned associations between diverse stimuli, actions, and their consequences. They can even convey abstract behavioral information such as "rules." This representation of the formal demands of tasks within the prefrontal cortex may provide the necessary foundation for the complex forms of behavior observed in primates, in whom this structure is most elaborate.


Earl K. Miller received his Ph.D. in Psychology and Neuroscience from Princeton University. After postdoctoral training at the National Institute of Mental Health, he joined the Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory at MIT in 1995. 


Rigotti, M., Barak, O., Warden, M.R., Wang, X., Daw, N.D., Miller, E.K., & Fusi, S. “The importance of mixed selectivity in complex cognitive tasks”. Nature, 497, 585-590, 2013 doi:10.1038/nature12160

Miller, E.K. and Buschman, T.J. “Brain Rhythms for Cognition and Consciousness”. Neurosciences and the Human Person: New Perspectives on Human Activities A. Battro, S. Dehaene and W. Singer (eds), Pontifical Academy of Sciences, Scripta Varia 121, Vatican City, 2013.

Miller, E.K. and Fusi, S. (2013) Limber neurons for a nimble mind. Neuron. 78:211-213.

Duncan, J. and Miller, E.K. (2013) Adaptive neural coding in frontal and parietal cortex. In: Stuss, D.T. and Knight, R.T. (Eds). Principles of Frontal Lobe Function: Second Edition.

Miller, E.K. and Fusi, S. (2013) Limber neurons for a nimble mind. Neuron. 78:211-213.

Miller, E.K. and Buschman, T.J. (2013) Cortical circuits for the control of attention. Current Opinion in Neurobiology.

Selected Awards 

Distinguished Member, National Society of Collegiate Scholars, 2013

National Institute of Mental Health MERIT Award

Mathilde Solowey Award in the Neurosciences

Election to the International Neuropsychological Symposium

Fellow of the American Association for the Advancement of Science

The Picower Chair at MIT

The National Academy of Sciences Troland Research Award

The Society for Neuroscience Young Investigator Award

The Pew Scholar Award

The John Merck Scholar Award

The McKnight Scholar Award